Fiber Specific Changes in Sphingolipid Metabolism in Skeletal Muscles of Hyperthyroid Rats
Thyroid hormones (T 3 , T 4 ) are well known modulators of different cellular signals including the sphingomyelin pathway. However, studies regarding downstream effects of T 3 on sphingolipid metabolism in skeletal muscle are scarce. In the present work we sought to investigate the effects of hypert...
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| Veröffentlicht in: | Lipids 2013-07, Vol.48 (7), p.697-704 |
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| creator | Chabowski, A. Żendzian-Piotrowska, M. Mikłosz, A. Łukaszuk, B. Kurek, K. Górski, J. |
| description | Thyroid hormones (T
3
, T
4
) are well known modulators of different cellular signals including the sphingomyelin pathway. However, studies regarding downstream effects of T
3
on sphingolipid metabolism in skeletal muscle are scarce. In the present work we sought to investigate the effects of hyperthyroidism on the activity of the key enzymes of ceramide metabolism as well as the content of fundamental sphingolipids. Based on fiber/metabolic differences, we chose three different skeletal muscles, with diverse fiber compositions: soleus (slow-twitch oxidative), red (fast-twitch oxidative-glycolytic) and white (fast-twitch glycolytic) section of gastrocnemius. We demonstrated that T
3
induced accumulation of sphinganine, ceramide, sphingosine, as well as sphingomyelin, mostly in soleus and in red, but not white section of gastrocnemius. Concomitantly, the activity of serine palmitoyltransferase and acid/neutral ceramidase was increased in more oxidative muscles. In conclusion, hyperthyroidism induced fiber specific changes in the content of sphingolipids that were relatively more related to de novo synthesis of ceramide rather than to its generation via hydrolysis of sphingomyelin. |
| doi_str_mv | 10.1007/s11745-013-3769-3 |
| format | Article |
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3
, T
4
) are well known modulators of different cellular signals including the sphingomyelin pathway. However, studies regarding downstream effects of T
3
on sphingolipid metabolism in skeletal muscle are scarce. In the present work we sought to investigate the effects of hyperthyroidism on the activity of the key enzymes of ceramide metabolism as well as the content of fundamental sphingolipids. Based on fiber/metabolic differences, we chose three different skeletal muscles, with diverse fiber compositions: soleus (slow-twitch oxidative), red (fast-twitch oxidative-glycolytic) and white (fast-twitch glycolytic) section of gastrocnemius. We demonstrated that T
3
induced accumulation of sphinganine, ceramide, sphingosine, as well as sphingomyelin, mostly in soleus and in red, but not white section of gastrocnemius. Concomitantly, the activity of serine palmitoyltransferase and acid/neutral ceramidase was increased in more oxidative muscles. In conclusion, hyperthyroidism induced fiber specific changes in the content of sphingolipids that were relatively more related to de novo synthesis of ceramide rather than to its generation via hydrolysis of sphingomyelin.</description><identifier>ISSN: 0024-4201</identifier><identifier>EISSN: 1558-9307</identifier><identifier>DOI: 10.1007/s11745-013-3769-3</identifier><identifier>PMID: 23467817</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Animals ; Biomedical and Life Sciences ; Ceramide ; Ceramides - agonists ; Ceramides - biosynthesis ; Hormones ; Hyperthyroidism - metabolism ; Hyperthyroidism - pathology ; Injections, Subcutaneous ; Life Sciences ; Lipidology ; Male ; Medical Biochemistry ; Medicinal Chemistry ; Microbial Genetics and Genomics ; Muscle, Skeletal - drug effects ; Muscle, Skeletal - metabolism ; Muscles ; Neurochemistry ; Neutral Ceramidase - metabolism ; Nutrition ; Organ Specificity ; Original ; Original Article ; Rats ; Rats, Wistar ; Serine C-Palmitoyltransferase - metabolism ; Skeletal muscle ; Sphingolipids ; Sphingomyelins - agonists ; Sphingomyelins - biosynthesis ; Sphingosine - agonists ; Sphingosine - analogs & derivatives ; Sphingosine - biosynthesis ; Thyroid ; Thyroid Gland - metabolism ; Thyroid Gland - pathology ; Triiodothyronine ; Triiodothyronine - pharmacology</subject><ispartof>Lipids, 2013-07, Vol.48 (7), p.697-704</ispartof><rights>The Author(s) 2013</rights><rights>2013 American Oil Chemists' Society (AOCS)</rights><rights>AOCS 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5517-cbda569a4df5bfafaa1e3eceb2bea938e8e192d72e4fffbe7670db1db3c005e63</citedby><cites>FETCH-LOGICAL-c5517-cbda569a4df5bfafaa1e3eceb2bea938e8e192d72e4fffbe7670db1db3c005e63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11745-013-3769-3$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11745-013-3769-3$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,41488,42557,45574,45575,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23467817$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chabowski, A.</creatorcontrib><creatorcontrib>Żendzian-Piotrowska, M.</creatorcontrib><creatorcontrib>Mikłosz, A.</creatorcontrib><creatorcontrib>Łukaszuk, B.</creatorcontrib><creatorcontrib>Kurek, K.</creatorcontrib><creatorcontrib>Górski, J.</creatorcontrib><title>Fiber Specific Changes in Sphingolipid Metabolism in Skeletal Muscles of Hyperthyroid Rats</title><title>Lipids</title><addtitle>Lipids</addtitle><addtitle>Lipids</addtitle><description>Thyroid hormones (T
3
, T
4
) are well known modulators of different cellular signals including the sphingomyelin pathway. However, studies regarding downstream effects of T
3
on sphingolipid metabolism in skeletal muscle are scarce. In the present work we sought to investigate the effects of hyperthyroidism on the activity of the key enzymes of ceramide metabolism as well as the content of fundamental sphingolipids. Based on fiber/metabolic differences, we chose three different skeletal muscles, with diverse fiber compositions: soleus (slow-twitch oxidative), red (fast-twitch oxidative-glycolytic) and white (fast-twitch glycolytic) section of gastrocnemius. We demonstrated that T
3
induced accumulation of sphinganine, ceramide, sphingosine, as well as sphingomyelin, mostly in soleus and in red, but not white section of gastrocnemius. Concomitantly, the activity of serine palmitoyltransferase and acid/neutral ceramidase was increased in more oxidative muscles. In conclusion, hyperthyroidism induced fiber specific changes in the content of sphingolipids that were relatively more related to de novo synthesis of ceramide rather than to its generation via hydrolysis of sphingomyelin.</description><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Ceramide</subject><subject>Ceramides - agonists</subject><subject>Ceramides - biosynthesis</subject><subject>Hormones</subject><subject>Hyperthyroidism - metabolism</subject><subject>Hyperthyroidism - pathology</subject><subject>Injections, Subcutaneous</subject><subject>Life Sciences</subject><subject>Lipidology</subject><subject>Male</subject><subject>Medical Biochemistry</subject><subject>Medicinal Chemistry</subject><subject>Microbial Genetics and Genomics</subject><subject>Muscle, Skeletal - drug effects</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Muscles</subject><subject>Neurochemistry</subject><subject>Neutral Ceramidase - metabolism</subject><subject>Nutrition</subject><subject>Organ Specificity</subject><subject>Original</subject><subject>Original Article</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Serine C-Palmitoyltransferase - metabolism</subject><subject>Skeletal muscle</subject><subject>Sphingolipids</subject><subject>Sphingomyelins - agonists</subject><subject>Sphingomyelins - biosynthesis</subject><subject>Sphingosine - agonists</subject><subject>Sphingosine - analogs & derivatives</subject><subject>Sphingosine - biosynthesis</subject><subject>Thyroid</subject><subject>Thyroid Gland - metabolism</subject><subject>Thyroid Gland - pathology</subject><subject>Triiodothyronine</subject><subject>Triiodothyronine - pharmacology</subject><issn>0024-4201</issn><issn>1558-9307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkk9v1DAQxS0EotvCB-CCInHhEuqJ7Ti5IKGF0kpbteLPhYtlO-Ndl2yS2gnVfnu8pK0KEurJ9szvPY39TMgroO-AUnkcASQXOQWWM1nWOXtCFiBEldeMyqdkQWnBc15QOCCHMV6lI_BaPCcHBeOlrEAuyI8TbzBkXwe03nmbLTe6W2PMfJdqG9-t-9YPvsnOcdQm7eP2T-sntqnQZudTtG3Ce5ed7gYM42YX-oR_0WN8QZ453UZ8ebseke8nn74tT_PVxeez5YdVboUAmVvTaFHWmjdOGKed1oAMLZrCoK5ZhRVCXTSyQO6cMyhLSRsDjWGWUoElOyLvZ99hMltsLHZj0K0agt_qsFO99urvTuc3at3_UqysKVQ8Gby9NQj99YRxVFsfLbat7rCfogIOhaBCMngcZRIKSSWXCX3zD3rVT6FLL7GnaIpFgEgUzJQNfYwB3f3cQNU-ZDWHrFLIah-yYknz-uGF7xV3qSZAzsCNb3H3uKNanV1-pGW9VxazMiZR-gjhwdD_nec3RF7EYQ</recordid><startdate>201307</startdate><enddate>201307</enddate><creator>Chabowski, A.</creator><creator>Żendzian-Piotrowska, M.</creator><creator>Mikłosz, A.</creator><creator>Łukaszuk, B.</creator><creator>Kurek, K.</creator><creator>Górski, J.</creator><general>Springer-Verlag</general><general>Springer‐Verlag</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201307</creationdate><title>Fiber Specific Changes in Sphingolipid Metabolism in Skeletal Muscles of Hyperthyroid Rats</title><author>Chabowski, A. ; Żendzian-Piotrowska, M. ; Mikłosz, A. ; Łukaszuk, B. ; Kurek, K. ; Górski, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5517-cbda569a4df5bfafaa1e3eceb2bea938e8e192d72e4fffbe7670db1db3c005e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Ceramide</topic><topic>Ceramides - agonists</topic><topic>Ceramides - biosynthesis</topic><topic>Hormones</topic><topic>Hyperthyroidism - metabolism</topic><topic>Hyperthyroidism - pathology</topic><topic>Injections, Subcutaneous</topic><topic>Life Sciences</topic><topic>Lipidology</topic><topic>Male</topic><topic>Medical Biochemistry</topic><topic>Medicinal Chemistry</topic><topic>Microbial Genetics and Genomics</topic><topic>Muscle, Skeletal - drug effects</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Muscles</topic><topic>Neurochemistry</topic><topic>Neutral Ceramidase - metabolism</topic><topic>Nutrition</topic><topic>Organ Specificity</topic><topic>Original</topic><topic>Original Article</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Serine C-Palmitoyltransferase - metabolism</topic><topic>Skeletal muscle</topic><topic>Sphingolipids</topic><topic>Sphingomyelins - agonists</topic><topic>Sphingomyelins - biosynthesis</topic><topic>Sphingosine - agonists</topic><topic>Sphingosine - analogs & derivatives</topic><topic>Sphingosine - biosynthesis</topic><topic>Thyroid</topic><topic>Thyroid Gland - metabolism</topic><topic>Thyroid Gland - pathology</topic><topic>Triiodothyronine</topic><topic>Triiodothyronine - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chabowski, A.</creatorcontrib><creatorcontrib>Żendzian-Piotrowska, M.</creatorcontrib><creatorcontrib>Mikłosz, A.</creatorcontrib><creatorcontrib>Łukaszuk, B.</creatorcontrib><creatorcontrib>Kurek, K.</creatorcontrib><creatorcontrib>Górski, J.</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Lipids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chabowski, A.</au><au>Żendzian-Piotrowska, M.</au><au>Mikłosz, A.</au><au>Łukaszuk, B.</au><au>Kurek, K.</au><au>Górski, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fiber Specific Changes in Sphingolipid Metabolism in Skeletal Muscles of Hyperthyroid Rats</atitle><jtitle>Lipids</jtitle><stitle>Lipids</stitle><addtitle>Lipids</addtitle><date>2013-07</date><risdate>2013</risdate><volume>48</volume><issue>7</issue><spage>697</spage><epage>704</epage><pages>697-704</pages><issn>0024-4201</issn><eissn>1558-9307</eissn><abstract>Thyroid hormones (T
3
, T
4
) are well known modulators of different cellular signals including the sphingomyelin pathway. However, studies regarding downstream effects of T
3
on sphingolipid metabolism in skeletal muscle are scarce. In the present work we sought to investigate the effects of hyperthyroidism on the activity of the key enzymes of ceramide metabolism as well as the content of fundamental sphingolipids. Based on fiber/metabolic differences, we chose three different skeletal muscles, with diverse fiber compositions: soleus (slow-twitch oxidative), red (fast-twitch oxidative-glycolytic) and white (fast-twitch glycolytic) section of gastrocnemius. We demonstrated that T
3
induced accumulation of sphinganine, ceramide, sphingosine, as well as sphingomyelin, mostly in soleus and in red, but not white section of gastrocnemius. Concomitantly, the activity of serine palmitoyltransferase and acid/neutral ceramidase was increased in more oxidative muscles. In conclusion, hyperthyroidism induced fiber specific changes in the content of sphingolipids that were relatively more related to de novo synthesis of ceramide rather than to its generation via hydrolysis of sphingomyelin.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>23467817</pmid><doi>10.1007/s11745-013-3769-3</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Lipids, 2013-07, Vol.48 (7), p.697-704 |
| issn | 0024-4201 1558-9307 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3690184 |
| source | MEDLINE; Wiley Journals; SpringerLink Journals - AutoHoldings |
| subjects | Animals Biomedical and Life Sciences Ceramide Ceramides - agonists Ceramides - biosynthesis Hormones Hyperthyroidism - metabolism Hyperthyroidism - pathology Injections, Subcutaneous Life Sciences Lipidology Male Medical Biochemistry Medicinal Chemistry Microbial Genetics and Genomics Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Muscles Neurochemistry Neutral Ceramidase - metabolism Nutrition Organ Specificity Original Original Article Rats Rats, Wistar Serine C-Palmitoyltransferase - metabolism Skeletal muscle Sphingolipids Sphingomyelins - agonists Sphingomyelins - biosynthesis Sphingosine - agonists Sphingosine - analogs & derivatives Sphingosine - biosynthesis Thyroid Thyroid Gland - metabolism Thyroid Gland - pathology Triiodothyronine Triiodothyronine - pharmacology |
| title | Fiber Specific Changes in Sphingolipid Metabolism in Skeletal Muscles of Hyperthyroid Rats |
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