Biological Activity of sym-Triazines with Acetylcholine-like Substitutions as Multitarget Modulators of Alzheimer’s Disease

The bioactivities of two novel compounds (TAE-1 and TAE-2) that contain a sym-triazine scaffold with acetylcholine-like substitutions are examined as promising candidate agents against Alzheimer’s disease. Inhibition of amyloid-β fibril formation in the presence of Aβ1–42, evaluated by Thioflavin T...

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Veröffentlicht in:	ACS chemical neuroscience 2013-06, Vol.4 (6), p.924-929
Hauptverfasser:	Veloso, Anthony J, Chow, Ari M, Dhar, Devjani, Tang, Derek W. F, Ganesh, Hashwin V.S, Mikhaylichenko, Svetlana, Brown, Ian R, Kerman, Kagan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - administration & dosage Acetylcholine - chemistry Alzheimer Disease - drug therapy Alzheimer Disease - pathology Amyloid beta-Peptides - chemistry Biological Products - administration & dosage Biological Products - chemistry Cell Differentiation - drug effects Cell Differentiation - physiology Cell Line, Tumor Drug Delivery Systems - methods Humans Letter Peptide Fragments - chemistry Protein Structure, Secondary Triazines - administration & dosage Triazines - chemistry
Online-Zugang:	Volltext
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