$Recombinant AAV9-TLK1B administration ameliorates fractionated radiation-induced xerostomia$

Recombinant AAV9-TLK1B administration ameliorates fractionated radiation-induced xerostomia

Salivary glands are highly susceptible to radiation, and patients with head and neck cancer treated with radiotherapy invariably suffer from its distressing side effect, salivary hypofunction. The reduction in saliva disrupts oral functions, and significantly impairs oral health. Previously, we demo...

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Veröffentlicht in:	Human gene therapy 2013-06, Vol.24 (6), p.604-612
Hauptverfasser:	Timiri Shanmugam, Prakash Srinivasan, Dayton, Robert D, Palaniyandi, Senthilnathan, Abreo, Fleurette, Caldito, Gloria, Klein, Ronald L, Sunavala-Dossabhoy, Gulshan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acinar Cells - pathology Animals Cell Line Dependovirus - metabolism Dose Fractionation Genetic Vectors HEK293 Cells Humans Male Protein-Serine-Threonine Kinases - metabolism Radiation Injuries - physiopathology Radiation Injuries - therapy Rats Rats, Sprague-Dawley Recombination, Genetic - genetics Salivation Submandibular Gland - metabolism Submandibular Gland - pathology Submandibular Gland - physiopathology Submandibular Gland - radiation effects Transduction, Genetic Transgenes Xerostomia - etiology Xerostomia - physiopathology Xerostomia - therapy
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