A truncated diphtheria toxin based recombinant porcine CTLA-4 fusion toxin

Targeted cell therapies are possible through the generation of recombinant fusion proteins that combine a toxin, such as diphtheria toxin (DT), with an antibody or other molecule that confers specificity. Upon binding of the fusion protein to the cell of interest, the diphtheria toxin is internalize...

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Veröffentlicht in:	Journal of immunological methods 2013-05, Vol.391 (1-2), p.103-111
Hauptverfasser:	Peraino, Jaclyn Stromp, Schenk, Marian, Zhang, Huiping, Li, Guoying, Hermanrud, Christina E., Neville, David M., Sachs, David H., Huang, Christene A., Duran-Struuck, Raimon, Wang, Zhirui
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antibodies antigen-presenting cells B-lymphocytes B7-1 Antigen - immunology B7-1 Antigen - metabolism cell death Cell Line CTLA-4 Antigen - administration & dosage CTLA-4 Antigen - biosynthesis CTLA-4 Antigen - genetics CTLA-4 Antigen - metabolism Diphtheria toxin Diphtheria Toxin - administration & dosage Diphtheria Toxin - biosynthesis Diphtheria Toxin - genetics Diphtheria Toxin - metabolism Flow Cytometry Fusion toxin genetic engineering Glycosylation Immunotherapy - methods Immunotoxins - administration & dosage Immunotoxins - genetics Immunotoxins - metabolism Interleukin Receptor Common gamma Subunit - deficiency Interleukin Receptor Common gamma Subunit - genetics interleukin-2 lymphoma Lymphoma, B-Cell - immunology Lymphoma, B-Cell - metabolism Lymphoma, B-Cell - therapy Mice Mice, Inbred NOD Mice, Knockout Mice, SCID neoplasm cells Pichia - genetics Pichia - metabolism Pichia pastoris Pichia pastoris expression Porcine antigen presenting cell Porcine CTLA-4 Protein Binding Protein Biosynthesis Protein Processing, Post-Translational protein synthesis recombinant fusion proteins Recombinant Fusion Proteins - metabolism Recombinant Fusion Proteins - pharmacology severe combined immunodeficiency Swine toxins yeasts
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