Polymeric immunoglobulin receptor traffics through two distinct apically targeted pathways in primary lacrimal gland acinar cells

The polymeric immunoglobulin receptor (pIgR) mediates transcytosis of dimeric immunoglobulin A (dIgA) and its release into mucosal secretions. The present study reveals the complexity of the trafficking of pIgR to the apical plasma membrane in epithelial cells with exocrine secretory functions; in r...

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Veröffentlicht in:	Journal of cell science 2013-06, Vol.126 (Pt 12), p.2704-2717
Hauptverfasser:	Xu, Shi, Ma, Linlin, Evans, Eunbyul, Okamoto, Curtis T, Hamm-Alvarez, Sarah F
Format:	Artikel
Sprache:	eng
Schlagworte:	Acinar Cells - metabolism Animals Cells, Cultured Endocytosis - physiology Epithelial Cells - metabolism Epithelial Cells - physiology Exocytosis - physiology Female Lacrimal Apparatus - metabolism Myosin Type V - metabolism Protein Transport - physiology rab GTP-Binding Proteins - metabolism rab3 GTP-Binding Proteins - metabolism Rabbits Receptors, Polymeric Immunoglobulin - metabolism Secretory Component - metabolism Secretory Component - physiology Secretory Vesicles - metabolism Secretory Vesicles - physiology trans-Golgi Network - metabolism Transcytosis - physiology
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