mTOR is a key modulator of ageing and age-related disease

Many experts in the biology of ageing believe that pharmacological interventions to slow ageing are a matter of 'when' rather than 'if'. A leading target for such interventions is the nutrient response pathway defined by the mechanistic target of rapamycin (mTOR). Inhibition of t...

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Veröffentlicht in:	Nature (London) 2013-01, Vol.493 (7432), p.338-345
Hauptverfasser:	Johnson, Simon C., Rabinovitch, Peter S., Kaeberlein, Matt
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208 631/208/212 Age Aging Aging - metabolism Aging - pathology Animals Autophagy Coronary restenosis Diet Disease Drug therapy Health aspects Humanities and Social Sciences Humans Insulin Insulin - metabolism Insulin-Like Growth Factor I - metabolism Kinases Longevity - genetics multidisciplinary Mutation Proteins review-article Risk factors Rodents Science Side effects Signal Transduction Studies TOR Serine-Threonine Kinases - metabolism Yeast
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