Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations

We used CDK4/hTERT-immortalized normal human bronchial epithelial cells (HBEC) from several individuals to study lung cancer pathogenesis by introducing combinations of common lung cancer oncogenic changes (p53, KRAS, and MYC) and followed the stepwise transformation of HBECs to full malignancy. Thi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular cancer research 2013-06, Vol.11 (6), p.638-650
Hauptverfasser:	Sato, Mitsuo, Larsen, Jill E, Lee, Woochang, Sun, Han, Shames, David S, Dalvi, Maithili P, Ramirez, Ruben D, Tang, Hao, DiMaio, John Michael, Gao, Boning, Xie, Yang, Wistuba, Ignacio I, Gazdar, Adi F, Shay, Jerry W, Minna, John D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bronchi - pathology Carcinogenesis - genetics Carcinogenesis - pathology Cell Differentiation Cell Line, Tumor Cell Proliferation Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - pathology Cellular Senescence Epithelial Cells - metabolism Epithelial Cells - pathology Epithelial-Mesenchymal Transition Female Gene Knockdown Techniques Humans Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - pathology Mice Mice, Inbred NOD Models, Biological Mutant Proteins - metabolism Paraffin Embedding Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-myc - metabolism Proto-Oncogene Proteins p21(ras) ras Proteins - metabolism Tissue Fixation Tumor Suppressor Protein p53 - metabolism Xenograft Model Antitumor Assays
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!