Metabolic alterations in lung cancer-associated fibroblasts correlated with increased glycolytic metabolism of the tumor

Cancer cells undergo a metabolic reprogramming but little is known about metabolic alterations of other cells within tumors. We use mass spectrometry-based profiling and a metabolic pathway-based systems analysis to compare 21 primary human lung cancer-associated fibroblast lines (CAF) to "norm...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Molecular cancer research 2013-06, Vol.11 (6), p.579-592
Hauptverfasser:	Chaudhri, Virendra K, Salzler, Gregory G, Dick, Salihah A, Buckman, Melanie S, Sordella, Raffaella, Karoly, Edward D, Mohney, Robert, Stiles, Brendon M, Elemento, Olivier, Altorki, Nasser K, McGraw, Timothy E
Format:	Artikel
Sprache:	eng
Schlagworte:	Autophagy - drug effects Cell Line, Transformed Cell Separation Fibroblasts - drug effects Fibroblasts - metabolism Fibroblasts - pathology Glucose - pharmacology Glycolysis - drug effects Humans Lung Neoplasms - metabolism Lung Neoplasms - pathology Metabolomics Microtubule-Associated Proteins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!