PGI2 signaling inhibits antigen uptake and increases migration of immature dendritic cells

Treatment of PGI2 analogs on immature DCs inhibits antigen uptake and increases migration from peripheral tissues to lymph nodes. PGI2 signaling through IP inhibits allergen‐induced inflammatory responses in mice. We reported previously that PGI2 analogs decreased proinflammatory cytokine and chemok...

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Veröffentlicht in:	Journal of leukocyte biology 2013-07, Vol.94 (1), p.77-88
Hauptverfasser:	Toki, Shinji, Goleniewska, Kasia, Huckabee, Matthew M., Zhou, Weisong, Newcomb, Dawn C., FitzGerald, Garret A., Lawson, William E., Peebles, R. Stokes
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Marrow Cells - metabolism CCR7 Cell Development, Differentiation, & Trafficking Cell Movement - drug effects Cell Movement - immunology Chemokine CCL19 - metabolism Chemokine CCL21 - metabolism Chemotaxis Cytokines - metabolism Dendritic Cells - drug effects Dendritic Cells - immunology Epoprostenol - pharmacology Female Flow Cytometry lymph node Male Mice Mice, Inbred C57BL Mice, Knockout Ovalbumin - immunology Ovalbumin - metabolism Platelet Aggregation Inhibitors - pharmacology podosome Receptors, CCR7 - metabolism Receptors, Epoprostenol - physiology Signal Transduction - drug effects
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