A bipolar functionality of Q/N‐rich proteins: Lsm4 amyloid causes clearance of yeast prions

Prions are epigenetic modifiers that cause partially loss‐of‐function phenotypes of the proteins in Saccharomyces cerevisiae. The molecular chaperone network that supports prion propagation in the cell has seen a great progress in the last decade. However, the cellular machinery to activate or deact...

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Veröffentlicht in:	MicrobiologyOpen (Weinheim) 2013-06, Vol.2 (3), p.415-430
Hauptverfasser:	Oishi, Keita, Kurahashi, Hiroshi, Pack, Chan‐Gi, Sako, Yasushi, Nakamura, Yoshikazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregates Amyloid Amyloid - metabolism Baking yeast Biology Correlation analysis Deactivation DNA Mutational Analysis Epigenetics Fluorescence Fluorescence spectroscopy Lsm4 Original Research Phenotypes Pin+ factor Plasmids Prion protein Prions Prions - metabolism Propagation Proteins Q/N‐rich protein Ribonucleoprotein, U4-U6 Small Nuclear - genetics Ribonucleoprotein, U4-U6 Small Nuclear - metabolism Saccharomyces cerevisiae Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Yeast yeast prion Yeasts
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