The Role of Xanthine Oxidase in Hemodialysis-Induced Oxidative Injury : Relationship with Nutritional Status

The role of xanthine oxidase (XOD) in patients undergoing chronic hemodialysis treatment (HD) is poorly understood. Geriatric nutritional risk index (GNRI) ≤ 90 could be linked with malnutrition-inflammation complex syndrome. This study measured XOD, myeloperoxidase (MPO), superoxide dismutase (SOD)...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oxidative medicine and cellular longevity 2013-01, Vol.2013 (2013), p.1-8
Hauptverfasser:	Stolic, Radojica V., Miric, Dijana, Janicijevic-Hudomal, Snezana, Mitic, Radoslav, Miric, Bratislav, Kisic, Bojana
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants - metabolism Biomarkers - blood Case-Control Studies Clinical Study Female Humans Kidney Failure, Chronic - blood Kidney Failure, Chronic - enzymology Kidney Failure, Chronic - pathology Male Middle Aged Multivariate Analysis Nutritional Status Oxidative Stress Peroxidase - blood Regression Analysis Renal Dialysis Superoxide Dismutase - blood Xanthine Oxidase - blood Xanthine Oxidase - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page	8
container_issue	2013
container_start_page	1
container_title	Oxidative medicine and cellular longevity
container_volume	2013
creator	Stolic, Radojica V. Miric, Dijana Janicijevic-Hudomal, Snezana Mitic, Radoslav Miric, Bratislav Kisic, Bojana
description	The role of xanthine oxidase (XOD) in patients undergoing chronic hemodialysis treatment (HD) is poorly understood. Geriatric nutritional risk index (GNRI) ≤ 90 could be linked with malnutrition-inflammation complex syndrome. This study measured XOD, myeloperoxidase (MPO), superoxide dismutase (SOD), lipid hydroperoxides, total free thiol groups, and advanced oxidation protein products (AOPP) in 50 HD patients before commencing (pre-HD) and immediately after completion of HD session (post-HD) and in 22 healthy controls. Pre-HD serum hydroperoxides, AOPP, XOD, and SOD were higher and total thiol groups were lower in patients than in controls (P 90 (P=0.002). In a multiple regression analysis, post-HD serum XOD activity was independently associated with GNRI ≤ 90 (β ± SE: 0.398 ± 0.151; P=0.012) and HD vintage (β ± SE: −0.349 ± 0.139; P=0.016). These results indicate that an upregulated XOD may be implicated in HD-induced oxidative injury contributing to accelerated protein damage in patients with GNRI ≤ 90.
doi_str_mv	10.1155/2013/245253
format	Article
fullrecord	<record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3684028</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1393819970</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-acad6e917b10208eaeda974fe649f2fd5e4c7b44bffcbb0fe1fc84d526c907bb3</originalsourceid><addsrcrecordid>eNqFkU1rFTEUhoMotlZXrpUsxTJtvuYjLgQp1l4oFmoFdyGTnDgpucl1kmm9_965TL3oqquE9zy8OeRB6DUlJ5TW9SkjlJ8yUbOaP0GHVApWESnF0_2dkAP0IudbQhrOBH2ODhjv6BzLQxRuBsDXKQBODv_QsQw-Ar767a3OgH3EF7BO1uuwzT5Xq2gnA3aZF38HeBVvp3GLP-BrCHOSYh78Bt_7MuCvUxn9LtIBfyu6TPkleuZ0yPDq4TxC388_35xdVJdXX1Znny4rI3hXKm20bUDStqeEkQ40WC1b4aAR0jFnaxCm7YXonTN9TxxQZzpha9YYSdq-50fo49K7mfo1WAOxjDqozejXetyqpL36fxL9oH6mO8WbThDWzQXvHgrG9GuCXNTaZwMh6AhpyopyuftB2ZIZPV5QM6acR3D7ZyhROz9q50ctfmb67b-b7dm_Qmbg_QLMHqy-94-0vVlgmBFweg-Luulayf8AnTik3w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1393819970</pqid></control><display><type>article</type><title>The Role of Xanthine Oxidase in Hemodialysis-Induced Oxidative Injury : Relationship with Nutritional Status</title><source>MEDLINE</source><source>Wiley Online Library Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>PubMed Central Open Access</source><creator>Stolic, Radojica V. ; Miric, Dijana ; Janicijevic-Hudomal, Snezana ; Mitic, Radoslav ; Miric, Bratislav ; Kisic, Bojana</creator><contributor>Ramana, Kota V.</contributor><creatorcontrib>Stolic, Radojica V. ; Miric, Dijana ; Janicijevic-Hudomal, Snezana ; Mitic, Radoslav ; Miric, Bratislav ; Kisic, Bojana ; Ramana, Kota V.</creatorcontrib><description>The role of xanthine oxidase (XOD) in patients undergoing chronic hemodialysis treatment (HD) is poorly understood. Geriatric nutritional risk index (GNRI) ≤ 90 could be linked with malnutrition-inflammation complex syndrome. This study measured XOD, myeloperoxidase (MPO), superoxide dismutase (SOD), lipid hydroperoxides, total free thiol groups, and advanced oxidation protein products (AOPP) in 50 HD patients before commencing (pre-HD) and immediately after completion of HD session (post-HD) and in 22 healthy controls. Pre-HD serum hydroperoxides, AOPP, XOD, and SOD were higher and total thiol groups were lower in patients than in controls (P<0.05, resp.). Compared to baseline values, serum MPO activity was increased irrespective of GNRI status. Serum XOD activity was increasing during HD treatment in the group with GNRI ≤ 90 (P=0.030) whilst decreasing in the group with GNRI > 90 (P=0.002). In a multiple regression analysis, post-HD serum XOD activity was independently associated with GNRI ≤ 90 (β ± SE: 0.398 ± 0.151; P=0.012) and HD vintage (β ± SE: −0.349 ± 0.139; P=0.016). These results indicate that an upregulated XOD may be implicated in HD-induced oxidative injury contributing to accelerated protein damage in patients with GNRI ≤ 90.</description><identifier>ISSN: 1942-0900</identifier><identifier>EISSN: 1942-0994</identifier><identifier>DOI: 10.1155/2013/245253</identifier><identifier>PMID: 23819009</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Antioxidants - metabolism ; Biomarkers - blood ; Case-Control Studies ; Clinical Study ; Female ; Humans ; Kidney Failure, Chronic - blood ; Kidney Failure, Chronic - enzymology ; Kidney Failure, Chronic - pathology ; Male ; Middle Aged ; Multivariate Analysis ; Nutritional Status ; Oxidative Stress ; Peroxidase - blood ; Regression Analysis ; Renal Dialysis ; Superoxide Dismutase - blood ; Xanthine Oxidase - blood ; Xanthine Oxidase - metabolism</subject><ispartof>Oxidative medicine and cellular longevity, 2013-01, Vol.2013 (2013), p.1-8</ispartof><rights>Copyright © 2013 Dijana Miric et al.</rights><rights>Copyright © 2013 Dijana Miric et al. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-acad6e917b10208eaeda974fe649f2fd5e4c7b44bffcbb0fe1fc84d526c907bb3</citedby><cites>FETCH-LOGICAL-c438t-acad6e917b10208eaeda974fe649f2fd5e4c7b44bffcbb0fe1fc84d526c907bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684028/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684028/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23819009$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Ramana, Kota V.</contributor><creatorcontrib>Stolic, Radojica V.</creatorcontrib><creatorcontrib>Miric, Dijana</creatorcontrib><creatorcontrib>Janicijevic-Hudomal, Snezana</creatorcontrib><creatorcontrib>Mitic, Radoslav</creatorcontrib><creatorcontrib>Miric, Bratislav</creatorcontrib><creatorcontrib>Kisic, Bojana</creatorcontrib><title>The Role of Xanthine Oxidase in Hemodialysis-Induced Oxidative Injury : Relationship with Nutritional Status</title><title>Oxidative medicine and cellular longevity</title><addtitle>Oxid Med Cell Longev</addtitle><description>The role of xanthine oxidase (XOD) in patients undergoing chronic hemodialysis treatment (HD) is poorly understood. Geriatric nutritional risk index (GNRI) ≤ 90 could be linked with malnutrition-inflammation complex syndrome. This study measured XOD, myeloperoxidase (MPO), superoxide dismutase (SOD), lipid hydroperoxides, total free thiol groups, and advanced oxidation protein products (AOPP) in 50 HD patients before commencing (pre-HD) and immediately after completion of HD session (post-HD) and in 22 healthy controls. Pre-HD serum hydroperoxides, AOPP, XOD, and SOD were higher and total thiol groups were lower in patients than in controls (P<0.05, resp.). Compared to baseline values, serum MPO activity was increased irrespective of GNRI status. Serum XOD activity was increasing during HD treatment in the group with GNRI ≤ 90 (P=0.030) whilst decreasing in the group with GNRI > 90 (P=0.002). In a multiple regression analysis, post-HD serum XOD activity was independently associated with GNRI ≤ 90 (β ± SE: 0.398 ± 0.151; P=0.012) and HD vintage (β ± SE: −0.349 ± 0.139; P=0.016). These results indicate that an upregulated XOD may be implicated in HD-induced oxidative injury contributing to accelerated protein damage in patients with GNRI ≤ 90.</description><subject>Antioxidants - metabolism</subject><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>Clinical Study</subject><subject>Female</subject><subject>Humans</subject><subject>Kidney Failure, Chronic - blood</subject><subject>Kidney Failure, Chronic - enzymology</subject><subject>Kidney Failure, Chronic - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Nutritional Status</subject><subject>Oxidative Stress</subject><subject>Peroxidase - blood</subject><subject>Regression Analysis</subject><subject>Renal Dialysis</subject><subject>Superoxide Dismutase - blood</subject><subject>Xanthine Oxidase - blood</subject><subject>Xanthine Oxidase - metabolism</subject><issn>1942-0900</issn><issn>1942-0994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><recordid>eNqFkU1rFTEUhoMotlZXrpUsxTJtvuYjLgQp1l4oFmoFdyGTnDgpucl1kmm9_965TL3oqquE9zy8OeRB6DUlJ5TW9SkjlJ8yUbOaP0GHVApWESnF0_2dkAP0IudbQhrOBH2ODhjv6BzLQxRuBsDXKQBODv_QsQw-Ar767a3OgH3EF7BO1uuwzT5Xq2gnA3aZF38HeBVvp3GLP-BrCHOSYh78Bt_7MuCvUxn9LtIBfyu6TPkleuZ0yPDq4TxC388_35xdVJdXX1Znny4rI3hXKm20bUDStqeEkQ40WC1b4aAR0jFnaxCm7YXonTN9TxxQZzpha9YYSdq-50fo49K7mfo1WAOxjDqozejXetyqpL36fxL9oH6mO8WbThDWzQXvHgrG9GuCXNTaZwMh6AhpyopyuftB2ZIZPV5QM6acR3D7ZyhROz9q50ctfmb67b-b7dm_Qmbg_QLMHqy-94-0vVlgmBFweg-Luulayf8AnTik3w</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Stolic, Radojica V.</creator><creator>Miric, Dijana</creator><creator>Janicijevic-Hudomal, Snezana</creator><creator>Mitic, Radoslav</creator><creator>Miric, Bratislav</creator><creator>Kisic, Bojana</creator><general>Hindawi Puplishing Corporation</general><general>Hindawi Publishing Corporation</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130101</creationdate><title>The Role of Xanthine Oxidase in Hemodialysis-Induced Oxidative Injury : Relationship with Nutritional Status</title><author>Stolic, Radojica V. ; Miric, Dijana ; Janicijevic-Hudomal, Snezana ; Mitic, Radoslav ; Miric, Bratislav ; Kisic, Bojana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-acad6e917b10208eaeda974fe649f2fd5e4c7b44bffcbb0fe1fc84d526c907bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Antioxidants - metabolism</topic><topic>Biomarkers - blood</topic><topic>Case-Control Studies</topic><topic>Clinical Study</topic><topic>Female</topic><topic>Humans</topic><topic>Kidney Failure, Chronic - blood</topic><topic>Kidney Failure, Chronic - enzymology</topic><topic>Kidney Failure, Chronic - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Nutritional Status</topic><topic>Oxidative Stress</topic><topic>Peroxidase - blood</topic><topic>Regression Analysis</topic><topic>Renal Dialysis</topic><topic>Superoxide Dismutase - blood</topic><topic>Xanthine Oxidase - blood</topic><topic>Xanthine Oxidase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stolic, Radojica V.</creatorcontrib><creatorcontrib>Miric, Dijana</creatorcontrib><creatorcontrib>Janicijevic-Hudomal, Snezana</creatorcontrib><creatorcontrib>Mitic, Radoslav</creatorcontrib><creatorcontrib>Miric, Bratislav</creatorcontrib><creatorcontrib>Kisic, Bojana</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oxidative medicine and cellular longevity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stolic, Radojica V.</au><au>Miric, Dijana</au><au>Janicijevic-Hudomal, Snezana</au><au>Mitic, Radoslav</au><au>Miric, Bratislav</au><au>Kisic, Bojana</au><au>Ramana, Kota V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Role of Xanthine Oxidase in Hemodialysis-Induced Oxidative Injury : Relationship with Nutritional Status</atitle><jtitle>Oxidative medicine and cellular longevity</jtitle><addtitle>Oxid Med Cell Longev</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>2013</volume><issue>2013</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>1942-0900</issn><eissn>1942-0994</eissn><abstract>The role of xanthine oxidase (XOD) in patients undergoing chronic hemodialysis treatment (HD) is poorly understood. Geriatric nutritional risk index (GNRI) ≤ 90 could be linked with malnutrition-inflammation complex syndrome. This study measured XOD, myeloperoxidase (MPO), superoxide dismutase (SOD), lipid hydroperoxides, total free thiol groups, and advanced oxidation protein products (AOPP) in 50 HD patients before commencing (pre-HD) and immediately after completion of HD session (post-HD) and in 22 healthy controls. Pre-HD serum hydroperoxides, AOPP, XOD, and SOD were higher and total thiol groups were lower in patients than in controls (P<0.05, resp.). Compared to baseline values, serum MPO activity was increased irrespective of GNRI status. Serum XOD activity was increasing during HD treatment in the group with GNRI ≤ 90 (P=0.030) whilst decreasing in the group with GNRI > 90 (P=0.002). In a multiple regression analysis, post-HD serum XOD activity was independently associated with GNRI ≤ 90 (β ± SE: 0.398 ± 0.151; P=0.012) and HD vintage (β ± SE: −0.349 ± 0.139; P=0.016). These results indicate that an upregulated XOD may be implicated in HD-induced oxidative injury contributing to accelerated protein damage in patients with GNRI ≤ 90.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>23819009</pmid><doi>10.1155/2013/245253</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
fulltext	fulltext
identifier	ISSN: 1942-0900
ispartof	Oxidative medicine and cellular longevity, 2013-01, Vol.2013 (2013), p.1-8
issn	1942-0900 1942-0994
language	eng
recordid	cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3684028
source	MEDLINE; Wiley Online Library Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access
subjects	Antioxidants - metabolism Biomarkers - blood Case-Control Studies Clinical Study Female Humans Kidney Failure, Chronic - blood Kidney Failure, Chronic - enzymology Kidney Failure, Chronic - pathology Male Middle Aged Multivariate Analysis Nutritional Status Oxidative Stress Peroxidase - blood Regression Analysis Renal Dialysis Superoxide Dismutase - blood Xanthine Oxidase - blood Xanthine Oxidase - metabolism
title	The Role of Xanthine Oxidase in Hemodialysis-Induced Oxidative Injury : Relationship with Nutritional Status
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T13%3A50%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Role%20of%20Xanthine%20Oxidase%20in%20Hemodialysis-Induced%20Oxidative%20Injury%20:%20Relationship%20with%20Nutritional%20Status&rft.jtitle=Oxidative%20medicine%20and%20cellular%20longevity&rft.au=Stolic,%20Radojica%20V.&rft.date=2013-01-01&rft.volume=2013&rft.issue=2013&rft.spage=1&rft.epage=8&rft.pages=1-8&rft.issn=1942-0900&rft.eissn=1942-0994&rft_id=info:doi/10.1155/2013/245253&rft_dat=%3Cproquest_pubme%3E1393819970%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1393819970&rft_id=info:pmid/23819009&rfr_iscdi=true