Quantitative Cranial Magnetic Resonance Imaging in Neonatal Hypoxic-Ischemic Encephalopathy
Abstract The volume of acute injury detected by diffusion-weighted imaging and quantitative brain growth on serial cranial magnetic resonance imaging was not previously used to predict neurodevelopmental outcomes in infants with neonatal hypoxic-ischemic encephalopathy treated with head cooling. Our...
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| Veröffentlicht in: | Pediatric neurology 2012-08, Vol.47 (2), p.101-108 |
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| container_title | Pediatric neurology |
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| creator | Mulkey, Sarah B., MD Yap, Vivien L., MD Swearingen, Christopher J., PhD Riggins, Melissa S., BS Kaiser, Jeffrey R., MD, MA Schaefer, G. Bradley, MD |
| description | Abstract The volume of acute injury detected by diffusion-weighted imaging and quantitative brain growth on serial cranial magnetic resonance imaging was not previously used to predict neurodevelopmental outcomes in infants with neonatal hypoxic-ischemic encephalopathy treated with head cooling. Our longitudinal study involved 16 head-cooled term infants with hypoxic-ischemic encephalopathy who underwent early and follow-up cranial magnetic resonance imaging and follow-up neurologic evaluations, out of 105 infants who received therapeutic hypothermia. The volume of acute injury was measured on initial cranial magnetic resonance imaging, using diffusion-weighted images. Total brain volumes were measured in both early and follow-up magnetic resonance imaging studies. Acute injury volume in the corpus callosum >0.5 cm3 was associated with developing epilepsy (odds ratio, 20; 95% confidence interval, 1.01-1059.6; P = 0.013). Follow-up whole brain volume was reduced in those with unfavorable outcomes (i.e., epilepsy, cerebral palsy, and delayed developmental milestones), compared with infants without all three outcomes. Although acute brain injury volume and brain growth measurements may be useful predictors of outcomes in neonatal hypoxic-ischemic encephalopathy, the evolution of brain injury in these infants has yet to be fully understood and should be studied prospectively. |
| doi_str_mv | 10.1016/j.pediatrneurol.2012.05.009 |
| format | Article |
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Bradley, MD</creator><creatorcontrib>Mulkey, Sarah B., MD ; Yap, Vivien L., MD ; Swearingen, Christopher J., PhD ; Riggins, Melissa S., BS ; Kaiser, Jeffrey R., MD, MA ; Schaefer, G. Bradley, MD</creatorcontrib><description>Abstract The volume of acute injury detected by diffusion-weighted imaging and quantitative brain growth on serial cranial magnetic resonance imaging was not previously used to predict neurodevelopmental outcomes in infants with neonatal hypoxic-ischemic encephalopathy treated with head cooling. Our longitudinal study involved 16 head-cooled term infants with hypoxic-ischemic encephalopathy who underwent early and follow-up cranial magnetic resonance imaging and follow-up neurologic evaluations, out of 105 infants who received therapeutic hypothermia. The volume of acute injury was measured on initial cranial magnetic resonance imaging, using diffusion-weighted images. Total brain volumes were measured in both early and follow-up magnetic resonance imaging studies. Acute injury volume in the corpus callosum >0.5 cm3 was associated with developing epilepsy (odds ratio, 20; 95% confidence interval, 1.01-1059.6; P = 0.013). Follow-up whole brain volume was reduced in those with unfavorable outcomes (i.e., epilepsy, cerebral palsy, and delayed developmental milestones), compared with infants without all three outcomes. Although acute brain injury volume and brain growth measurements may be useful predictors of outcomes in neonatal hypoxic-ischemic encephalopathy, the evolution of brain injury in these infants has yet to be fully understood and should be studied prospectively.</description><identifier>ISSN: 0887-8994</identifier><identifier>EISSN: 1873-5150</identifier><identifier>DOI: 10.1016/j.pediatrneurol.2012.05.009</identifier><identifier>PMID: 22759685</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Biological and medical sciences ; Brain - pathology ; Cryotherapy - methods ; Female ; Follow-Up Studies ; Humans ; Hypoxia-Ischemia, Brain - diagnosis ; Hypoxia-Ischemia, Brain - therapy ; Infant ; Infant, Newborn ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Imaging - standards ; Male ; Medical sciences ; Nervous system ; Neurology ; Organ Size ; Pediatrics ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Retrospective Studies</subject><ispartof>Pediatric neurology, 2012-08, Vol.47 (2), p.101-108</ispartof><rights>2012</rights><rights>2015 INIST-CNRS</rights><rights>Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c576t-5206e6ee4edb75d0b9bc9fa73c9381867b911ce6cec226f946521f3efd611c913</citedby><cites>FETCH-LOGICAL-c576t-5206e6ee4edb75d0b9bc9fa73c9381867b911ce6cec226f946521f3efd611c913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0887899412002226$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26160506$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22759685$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mulkey, Sarah B., MD</creatorcontrib><creatorcontrib>Yap, Vivien L., MD</creatorcontrib><creatorcontrib>Swearingen, Christopher J., PhD</creatorcontrib><creatorcontrib>Riggins, Melissa S., BS</creatorcontrib><creatorcontrib>Kaiser, Jeffrey R., MD, MA</creatorcontrib><creatorcontrib>Schaefer, G. Bradley, MD</creatorcontrib><title>Quantitative Cranial Magnetic Resonance Imaging in Neonatal Hypoxic-Ischemic Encephalopathy</title><title>Pediatric neurology</title><addtitle>Pediatr Neurol</addtitle><description>Abstract The volume of acute injury detected by diffusion-weighted imaging and quantitative brain growth on serial cranial magnetic resonance imaging was not previously used to predict neurodevelopmental outcomes in infants with neonatal hypoxic-ischemic encephalopathy treated with head cooling. Our longitudinal study involved 16 head-cooled term infants with hypoxic-ischemic encephalopathy who underwent early and follow-up cranial magnetic resonance imaging and follow-up neurologic evaluations, out of 105 infants who received therapeutic hypothermia. The volume of acute injury was measured on initial cranial magnetic resonance imaging, using diffusion-weighted images. Total brain volumes were measured in both early and follow-up magnetic resonance imaging studies. Acute injury volume in the corpus callosum >0.5 cm3 was associated with developing epilepsy (odds ratio, 20; 95% confidence interval, 1.01-1059.6; P = 0.013). Follow-up whole brain volume was reduced in those with unfavorable outcomes (i.e., epilepsy, cerebral palsy, and delayed developmental milestones), compared with infants without all three outcomes. Although acute brain injury volume and brain growth measurements may be useful predictors of outcomes in neonatal hypoxic-ischemic encephalopathy, the evolution of brain injury in these infants has yet to be fully understood and should be studied prospectively.</description><subject>Biological and medical sciences</subject><subject>Brain - pathology</subject><subject>Cryotherapy - methods</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Hypoxia-Ischemia, Brain - diagnosis</subject><subject>Hypoxia-Ischemia, Brain - therapy</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Imaging - standards</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous system</subject><subject>Neurology</subject><subject>Organ Size</subject><subject>Pediatrics</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Retrospective Studies</subject><issn>0887-8994</issn><issn>1873-5150</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkluL1DAUgIso7rj6F6Qggi-tuUzSBmFhGcbdgVXx9uRDSNPTmYxtUpN02Pn3ZpxxdX3yKXDynQvnO1n2AqMSI8xfb8sRWqOitzB515cEYVIiViIkHmQzXFe0YJihh9kM1XVV1ELMz7InIWwRQkyQ-ePsjJCKCV6zWfbt46RsNFFFs4N84ZU1qs_fqbWFaHT-CYKzymrIV4NaG7vOjc3fQ4rFhF3vR3drdLEKegNDwpeJHDeqd6OKm_3T7FGn-gDPTu959vXt8sviurj5cLVaXN4UmlU8FowgDhxgDm1TsRY1otGiUxXVgta45lUjMNbANWhCeCfmnBHcUehanuIC0_Ps4lh3nJoBWg02etXL0ZtB-b10ysj7P9Zs5NrtJOU1FbVIBV6dCnj3Y4IQ5WCChr5XFtwUJEaEMkprxBP65ohq70Lw0N21wUge9MitvKdHHvRIxGTSk7Kf_z3pXe5vHwl4eQJU0Krvkg9twh-OY47YrzGWRw7SXncGvAzaQNp-azzoKFtn_nOgi3_q6N5Yk1p_hz2ErZu8TeokliHlyM-HizocFCYIkWSD_gTz7s2v</recordid><startdate>20120801</startdate><enddate>20120801</enddate><creator>Mulkey, Sarah B., MD</creator><creator>Yap, Vivien L., MD</creator><creator>Swearingen, Christopher J., PhD</creator><creator>Riggins, Melissa S., BS</creator><creator>Kaiser, Jeffrey R., MD, MA</creator><creator>Schaefer, G. Bradley, MD</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120801</creationdate><title>Quantitative Cranial Magnetic Resonance Imaging in Neonatal Hypoxic-Ischemic Encephalopathy</title><author>Mulkey, Sarah B., MD ; Yap, Vivien L., MD ; Swearingen, Christopher J., PhD ; Riggins, Melissa S., BS ; Kaiser, Jeffrey R., MD, MA ; Schaefer, G. 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Bradley, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative Cranial Magnetic Resonance Imaging in Neonatal Hypoxic-Ischemic Encephalopathy</atitle><jtitle>Pediatric neurology</jtitle><addtitle>Pediatr Neurol</addtitle><date>2012-08-01</date><risdate>2012</risdate><volume>47</volume><issue>2</issue><spage>101</spage><epage>108</epage><pages>101-108</pages><issn>0887-8994</issn><eissn>1873-5150</eissn><abstract>Abstract The volume of acute injury detected by diffusion-weighted imaging and quantitative brain growth on serial cranial magnetic resonance imaging was not previously used to predict neurodevelopmental outcomes in infants with neonatal hypoxic-ischemic encephalopathy treated with head cooling. Our longitudinal study involved 16 head-cooled term infants with hypoxic-ischemic encephalopathy who underwent early and follow-up cranial magnetic resonance imaging and follow-up neurologic evaluations, out of 105 infants who received therapeutic hypothermia. The volume of acute injury was measured on initial cranial magnetic resonance imaging, using diffusion-weighted images. Total brain volumes were measured in both early and follow-up magnetic resonance imaging studies. Acute injury volume in the corpus callosum >0.5 cm3 was associated with developing epilepsy (odds ratio, 20; 95% confidence interval, 1.01-1059.6; P = 0.013). Follow-up whole brain volume was reduced in those with unfavorable outcomes (i.e., epilepsy, cerebral palsy, and delayed developmental milestones), compared with infants without all three outcomes. 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| ispartof | Pediatric neurology, 2012-08, Vol.47 (2), p.101-108 |
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| subjects | Biological and medical sciences Brain - pathology Cryotherapy - methods Female Follow-Up Studies Humans Hypoxia-Ischemia, Brain - diagnosis Hypoxia-Ischemia, Brain - therapy Infant Infant, Newborn Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging - standards Male Medical sciences Nervous system Neurology Organ Size Pediatrics Radiodiagnosis. Nmr imagery. Nmr spectrometry Retrospective Studies |
| title | Quantitative Cranial Magnetic Resonance Imaging in Neonatal Hypoxic-Ischemic Encephalopathy |
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