Integrating differentiation and cancer: The Nkx3.1 homeobox gene in prostate organogenesis and carcinogenesis
Several tissue-specific regulatory genes have been found to play essential roles in both organogenesis and carcinogenesis. In the prostate, the Nkx3.1 homeobox gene plays an important role in normal differentiation of the prostatic epithelium while its loss of function is an initiating event in pros...
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| Veröffentlicht in: | Differentiation (London) 2008-07, Vol.76 (6), p.717-727 |
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| creator | Abate-Shen, Cory Shen, Michael M. Gelmann, Edward |
| description | Several tissue-specific regulatory genes have been found to play essential roles in both organogenesis and carcinogenesis. In the prostate, the
Nkx3.1 homeobox gene plays an important role in normal differentiation of the prostatic epithelium while its loss of function is an initiating event in prostate carcinogenesis in both mouse models and human patients. Thus, the
Nkx3.1 homeobox gene provides a paradigm for understanding the relationship between normal differentiation and cancer, as well as studying the roles of homeobox genes in these processes. Here, we review recent findings concerning the roles of
Nkx3.1 in development and discuss how its normal function is disrupted in processes of early prostate carcinogenesis. |
| doi_str_mv | 10.1111/j.1432-0436.2008.00292.x |
| format | Article |
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Nkx3.1 homeobox gene plays an important role in normal differentiation of the prostatic epithelium while its loss of function is an initiating event in prostate carcinogenesis in both mouse models and human patients. Thus, the
Nkx3.1 homeobox gene provides a paradigm for understanding the relationship between normal differentiation and cancer, as well as studying the roles of homeobox genes in these processes. Here, we review recent findings concerning the roles of
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Nkx3.1 homeobox gene provides a paradigm for understanding the relationship between normal differentiation and cancer, as well as studying the roles of homeobox genes in these processes. Here, we review recent findings concerning the roles of
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| identifier | ISSN: 0301-4681 |
| ispartof | Differentiation (London), 2008-07, Vol.76 (6), p.717-727 |
| issn | 0301-4681 1432-0436 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3683569 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Cell Differentiation homeobox Homeodomain Proteins - genetics Homeodomain Proteins - physiology Humans Male Neoplasms - physiopathology nkx3.1 prostate Prostate - growth & development Prostate - pathology Transcription Factors - genetics Transcription Factors - physiology |
| title | Integrating differentiation and cancer: The Nkx3.1 homeobox gene in prostate organogenesis and carcinogenesis |
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