PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis

π-stacking interactions unique between residues of PUMA and Bcl-xL, which lead to the unfolding of Bcl-xL via an allosteric mechanism, are required to disrupt p53–Bcl-xL interaction and induce apoptosis. This is the first example of regulated protein unfolding for signal transmission. Following DNA...

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Veröffentlicht in:	Nat. Chem. Biol 2013-03, Vol.9 (3), p.163-168
Hauptverfasser:	Follis, Ariele Viacava, Chipuk, Jerry E, Fisher, John C, Yun, Mi-Kyung, Grace, Christy R, Nourse, Amanda, Baran, Katherine, Ou, Li, Min, Lie, White, Stephen W, Green, Douglas R, Kriwacki, Richard W
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/535 631/80/82/23 631/80/86 631/92/470 Apoptosis Apoptosis Regulatory Proteins - chemistry Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism bcl-X Protein - chemistry bcl-X Protein - metabolism Biochemical Engineering Biochemistry Bioorganic Chemistry Cell Biology Cellular biology Chemistry Chemistry/Food Science Crystallography Deoxyribonucleic acid DNA DNA damage Humans Models, Molecular Molecular biology Protein Unfolding Proteins Proto-Oncogene Proteins - chemistry Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Spectroscopy Tumor Suppressor Protein p53 - chemistry Tumor Suppressor Protein p53 - metabolism
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