Impact of chronic congestive heart failure on pharmacokinetics and vasomotor effects of infused nitrite

Background and Purpose Nitrite (NO2−) has recently been shown to represent a potential source of NO, in particular under hypoxic conditions. The aim of the current study was to compare the haemodynamic effects of NO2− in healthy volunteers and patients with stable congestive heart failure (CHF). Exp...

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Veröffentlicht in:	British journal of pharmacology 2013-06, Vol.169 (3), p.659-670
Hauptverfasser:	Maher, Abdul R, Arif, Sayqa, Madhani, Melanie, Abozguia, Khalid, Ahmed, Ibrar, Fernandez, Bernadette O, Feelisch, Martin, O'Sullivan, AG, Christopoulos, Arthur, Sverdlov, Aaron L, Ngo, Doan, Dautov, Rustem, James, Philip E, Horowitz, John D, Frenneaux, Michael P
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Brachial Artery Cohort Studies Drug Tolerance Female Forearm heart failure Heart Failure - drug therapy Heart Failure - metabolism Heart Failure - physiopathology Hemodynamics - drug effects Humans In Vitro Techniques Infusions, Intra-Arterial Male Metabolic Clearance Rate Middle Aged Nitric Oxide - administration & dosage Nitric Oxide - analogs & derivatives Nitric Oxide - metabolism Nitric Oxide - pharmacokinetics Nitroglycerin - administration & dosage Nitroglycerin - metabolism Nitroglycerin - pharmacokinetics Nitroglycerin - pharmacology Oxidative Stress - drug effects Regional Blood Flow - drug effects Research Papers Saphenous Vein - drug effects Saphenous Vein - physiopathology sodium nitrite Sodium Nitrite - administration & dosage Sodium Nitrite - metabolism Sodium Nitrite - pharmacokinetics Sodium Nitrite - pharmacology vascular effects Vasodilation - drug effects Vasodilator Agents - administration & dosage Vasodilator Agents - metabolism Vasodilator Agents - pharmacokinetics Vasodilator Agents - pharmacology Vasomotor System - drug effects Vasomotor System - physiopathology
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