Preclinical evaluation of the abuse potential of Pitolisant, a histamine H3 receptor inverse agonist/antagonist compared with Modafinil

Background and Purpose Pitolisant, a histamine H3 receptor inverse agonist/antagonist is currently under Phase III clinical trials for treatment of excessive daytime sleepiness namely in narcoleptic patients. Its drug abuse potential was investigated using in vivo models in rodents and monkeys and c...

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Veröffentlicht in:	British journal of pharmacology 2013-06, Vol.169 (3), p.632-644
Hauptverfasser:	Uguen, M, Perrin, D, Belliard, S, Ligneau, X, Beardsley, PM, Lecomte, JM, Schwartz, JC
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior, Addictive - chemically induced Behavior, Addictive - prevention & control Behavior, Animal - drug effects Benzhydryl Compounds - adverse effects Central Nervous System Stimulants - adverse effects Cocaine conditioned place preference discrimination Dopamine Dopamine - chemistry Dopamine - metabolism Dopaminergic Neurons - drug effects Dopaminergic Neurons - metabolism Dose-Response Relationship, Drug Drug abuse Drug Antagonism Drug Evaluation, Preclinical Drug Inverse Agonism Drugs, Investigational - administration & dosage Drugs, Investigational - adverse effects Drugs, Investigational - therapeutic use H3 receptor histamine Histamine Agonists - administration & dosage Histamine Agonists - adverse effects Histamine Agonists - therapeutic use Histamine Antagonists - administration & dosage Histamine Antagonists - adverse effects Histamine Antagonists - therapeutic use Macaca mulatta Male Mice Modafinil monkeys Motor Activity - drug effects Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Piperidines - administration & dosage Piperidines - adverse effects Piperidines - therapeutic use Pitolisant Rats Receptors, Histamine H3 - chemistry Receptors, Histamine H3 - metabolism Research Papers Rodents self‐administration sensitization Wakefulness-Promoting Agents - administration & dosage Wakefulness-Promoting Agents - adverse effects Wakefulness-Promoting Agents - therapeutic use
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