Gene Abstinence Effects on Drug Cue Reactivity in Addiction: Multimodal Evidence

Functional polymorphisms in the dopamine transporter gene (DAT1 or SLC6A3) modulate responsiveness to salient stimuli, such that carriers of one 9R-allele of DAT1 (compared with homozygote carriers of the 10R-allele) show heightened reactivity to drug-related reinforcement in addiction. Here, using...

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Veröffentlicht in:The Journal of neuroscience 2013-06, Vol.33 (24), p.10027-10036
Hauptverfasser: Moeller, Scott J, Parvaz, Muhammad A, Shumay, Elena, Beebe-Wang, Nicasia, Konova, Anna B, Alia-Klein, Nelly, Volkow, Nora D, Goldstein, Rita Z
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container_end_page 10036
container_issue 24
container_start_page 10027
container_title The Journal of neuroscience
container_volume 33
creator Moeller, Scott J
Parvaz, Muhammad A
Shumay, Elena
Beebe-Wang, Nicasia
Konova, Anna B
Alia-Klein, Nelly
Volkow, Nora D
Goldstein, Rita Z
description Functional polymorphisms in the dopamine transporter gene (DAT1 or SLC6A3) modulate responsiveness to salient stimuli, such that carriers of one 9R-allele of DAT1 (compared with homozygote carriers of the 10R-allele) show heightened reactivity to drug-related reinforcement in addiction. Here, using multimodal neuroimaging and behavioral dependent variables in 73 human cocaine-addicted individuals and 47 healthy controls, we hypothesized and found that cocaine-addicted carriers of a 9R-allele exhibited higher responses to drug cues, but only among individuals who had used cocaine within 72 h of the study as verified by positive cocaine urine screens (a state characterized by intense craving). Importantly, this responsiveness to drug cues was reliably preserved across multimodal imaging and behavioral probes: psychophysiological event-related potentials, self-report, simulated cocaine choice, and fMRI. Because drug cues contribute to relapse, our results identify the DAT1R 9R-allele as a vulnerability allele for relapse especially during early abstinence (e.g., detoxification).
doi_str_mv 10.1523/JNEUROSCI.0695-13.2013
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title Gene Abstinence Effects on Drug Cue Reactivity in Addiction: Multimodal Evidence
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