Comparative Evaluation of Pre-Emptive Analgesic Efficacy of Intramuscular Ketorolac Versus Tramadol Following Third Molar Surgery
Pre-emptive analgesia aims at preventing the central nervous system from reaching a hyper-excitable state known as central sensitization, in which it responds excessively to afferent inputs. The clinical implication would be more effective pain management, thereby reducing post-operative pain and an...
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| Veröffentlicht in: | Journal of maxillofacial and oral surgery 2013-06, Vol.12 (2), p.197-202 |
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| creator | Shah, Ashwin V. Arun Kumar, K. V. Rai, Kirthi Kumar Rajesh Kumar, B. P. |
| description | Pre-emptive analgesia aims at preventing the central nervous system from reaching a hyper-excitable state known as central sensitization, in which it responds excessively to afferent inputs. The clinical implication would be more effective pain management, thereby reducing post-operative pain and analgesic requirements. This study aimed at investigating the existence of pre-emptive analgesia and to compare the pre-emptive analgesic efficacy of im ketorolac [NSAID] versus tramadol [SYNTHETIC OPIOD] for post-operative pain management following third molar surgery. Fifty patients under the age group of 16–25 years with asymptomatic, symmetrically impacted mandibular third molars were equally divided into 2 groups and underwent third molar surgery under local anesthesia. Ketorolac 30 mg and tramadol 50 mg were used in the study group, while sodium chloride 0.9 % was used in the control group. Study parameters included pain intensity scores for 12 post-operative hours, time to 1st rescue analgesia, total number of analgesics consumed during the 5 post-operative days and patients’ self assessment of efficacy of the surgery with regardsto no pain. Statistically, the data are presented as the mean values with their standard deviations and a 95 % confidence interval [
p
is significant, if
p
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| doi_str_mv | 10.1007/s12663-012-0420-4 |
| format | Article |
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p
is significant, if
p
< 0.05] for the mean are applicable. Incidences of adverse events like pain on injection of the study drug, local reactions, nausea and vomiting were noted. Patients in the study group significantly performed better than the control group in terms of all the parameters; while among the study group, ketorolac fared better than tramadol. All the drug related complications were mild and did not require any intervention. Pre-operative ketorolac or tramadol in comparison to placebo resulted in a significantly better post-operative pain management. However as against tramadol, ketorolac is a better choice as a pre-emptive analgesic agent for the post-operative pain management following third molar surgery.</description><identifier>ISSN: 0972-8279</identifier><identifier>EISSN: 0974-942X</identifier><identifier>DOI: 10.1007/s12663-012-0420-4</identifier><identifier>PMID: 24431839</identifier><language>eng</language><publisher>India: Springer-Verlag</publisher><subject>Analgesics ; Asymptomatic ; Comparative Study ; Dentistry ; Medicine ; Medicine & Public Health ; Narcotics ; Oral and Maxillofacial Surgery ; Otorhinolaryngology ; Pain ; Patients ; Plastic Surgery ; Self evaluation ; Statistical analysis ; Surgery</subject><ispartof>Journal of maxillofacial and oral surgery, 2013-06, Vol.12 (2), p.197-202</ispartof><rights>Association of Oral and Maxillofacial Surgeons of India 2012</rights><rights>Association of Oral and Maxillofacial Surgeons of India 2012.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-c25370cfe0715fb504c5b6d08a5625c92c852be32e3f03c8c793c57c5a690a323</citedby><cites>FETCH-LOGICAL-c470t-c25370cfe0715fb504c5b6d08a5625c92c852be32e3f03c8c793c57c5a690a323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682004/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2919608615?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,315,728,781,785,886,21393,21394,27929,27930,33535,33536,33749,33750,41493,42562,43664,43810,51324,53796,53798,64390,64392,64394,72474</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24431839$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shah, Ashwin V.</creatorcontrib><creatorcontrib>Arun Kumar, K. V.</creatorcontrib><creatorcontrib>Rai, Kirthi Kumar</creatorcontrib><creatorcontrib>Rajesh Kumar, B. P.</creatorcontrib><title>Comparative Evaluation of Pre-Emptive Analgesic Efficacy of Intramuscular Ketorolac Versus Tramadol Following Third Molar Surgery</title><title>Journal of maxillofacial and oral surgery</title><addtitle>J. Maxillofac. Oral Surg</addtitle><addtitle>J Maxillofac Oral Surg</addtitle><description>Pre-emptive analgesia aims at preventing the central nervous system from reaching a hyper-excitable state known as central sensitization, in which it responds excessively to afferent inputs. The clinical implication would be more effective pain management, thereby reducing post-operative pain and analgesic requirements. This study aimed at investigating the existence of pre-emptive analgesia and to compare the pre-emptive analgesic efficacy of im ketorolac [NSAID] versus tramadol [SYNTHETIC OPIOD] for post-operative pain management following third molar surgery. Fifty patients under the age group of 16–25 years with asymptomatic, symmetrically impacted mandibular third molars were equally divided into 2 groups and underwent third molar surgery under local anesthesia. Ketorolac 30 mg and tramadol 50 mg were used in the study group, while sodium chloride 0.9 % was used in the control group. Study parameters included pain intensity scores for 12 post-operative hours, time to 1st rescue analgesia, total number of analgesics consumed during the 5 post-operative days and patients’ self assessment of efficacy of the surgery with regardsto no pain. Statistically, the data are presented as the mean values with their standard deviations and a 95 % confidence interval [
p
is significant, if
p
< 0.05] for the mean are applicable. Incidences of adverse events like pain on injection of the study drug, local reactions, nausea and vomiting were noted. Patients in the study group significantly performed better than the control group in terms of all the parameters; while among the study group, ketorolac fared better than tramadol. All the drug related complications were mild and did not require any intervention. Pre-operative ketorolac or tramadol in comparison to placebo resulted in a significantly better post-operative pain management. However as against tramadol, ketorolac is a better choice as a pre-emptive analgesic agent for the post-operative pain management following third molar surgery.</description><subject>Analgesics</subject><subject>Asymptomatic</subject><subject>Comparative Study</subject><subject>Dentistry</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Narcotics</subject><subject>Oral and Maxillofacial Surgery</subject><subject>Otorhinolaryngology</subject><subject>Pain</subject><subject>Patients</subject><subject>Plastic Surgery</subject><subject>Self evaluation</subject><subject>Statistical analysis</subject><subject>Surgery</subject><issn>0972-8279</issn><issn>0974-942X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kV1rFDEYhYNYbNn2B3gjAW-8ib75mMnkRijLVostCq7iXchmM9spmcmaTFb20n9uptvWDzA3CZwnJyfvQeg5hdcUQL5JlNU1J0AZAcGAiCfoBJQURAn27endmZGGSXWMzlK6hbI45YrTZ-iYCcFpw9UJ-jkP_dZEM3Y7hxc743M5hgGHFn-Kjiz67Z1yPhi_camzeNG2nTV2PxGXwxhNn5PN3kT8wY0hBm8s_upiygkvi2jWweOL4H340Q0bvLzp4hpfh4n_nOPGxf0pOmqNT-7sfp-hLxeL5fw9ufr47nJ-fkWskDASyyouwbYOJK3aVQXCVqt6DY2palZZxWxTsZXjzPEWuG2sVNxW0lamVmA44zP09uC7zavera2bwnu9jV1v4l4H0-m_laG70Zuw07xuGIAoBq_uDWL4nl0add8l67w3gws5aSrUlI03sqAv_0FvQ45lhkkzRVUNTV3AGaIHysaQUnTtYxgKeupYHzrWpWM9daynEC_-_MXjjYdGC8AOQCrSUAb8--n_u_4C5ZGzgQ</recordid><startdate>20130601</startdate><enddate>20130601</enddate><creator>Shah, Ashwin V.</creator><creator>Arun Kumar, K. 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V.</au><au>Rai, Kirthi Kumar</au><au>Rajesh Kumar, B. P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative Evaluation of Pre-Emptive Analgesic Efficacy of Intramuscular Ketorolac Versus Tramadol Following Third Molar Surgery</atitle><jtitle>Journal of maxillofacial and oral surgery</jtitle><stitle>J. Maxillofac. Oral Surg</stitle><addtitle>J Maxillofac Oral Surg</addtitle><date>2013-06-01</date><risdate>2013</risdate><volume>12</volume><issue>2</issue><spage>197</spage><epage>202</epage><pages>197-202</pages><issn>0972-8279</issn><eissn>0974-942X</eissn><abstract>Pre-emptive analgesia aims at preventing the central nervous system from reaching a hyper-excitable state known as central sensitization, in which it responds excessively to afferent inputs. The clinical implication would be more effective pain management, thereby reducing post-operative pain and analgesic requirements. This study aimed at investigating the existence of pre-emptive analgesia and to compare the pre-emptive analgesic efficacy of im ketorolac [NSAID] versus tramadol [SYNTHETIC OPIOD] for post-operative pain management following third molar surgery. Fifty patients under the age group of 16–25 years with asymptomatic, symmetrically impacted mandibular third molars were equally divided into 2 groups and underwent third molar surgery under local anesthesia. Ketorolac 30 mg and tramadol 50 mg were used in the study group, while sodium chloride 0.9 % was used in the control group. Study parameters included pain intensity scores for 12 post-operative hours, time to 1st rescue analgesia, total number of analgesics consumed during the 5 post-operative days and patients’ self assessment of efficacy of the surgery with regardsto no pain. Statistically, the data are presented as the mean values with their standard deviations and a 95 % confidence interval [
p
is significant, if
p
< 0.05] for the mean are applicable. Incidences of adverse events like pain on injection of the study drug, local reactions, nausea and vomiting were noted. Patients in the study group significantly performed better than the control group in terms of all the parameters; while among the study group, ketorolac fared better than tramadol. All the drug related complications were mild and did not require any intervention. Pre-operative ketorolac or tramadol in comparison to placebo resulted in a significantly better post-operative pain management. However as against tramadol, ketorolac is a better choice as a pre-emptive analgesic agent for the post-operative pain management following third molar surgery.</abstract><cop>India</cop><pub>Springer-Verlag</pub><pmid>24431839</pmid><doi>10.1007/s12663-012-0420-4</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Analgesics Asymptomatic Comparative Study Dentistry Medicine Medicine & Public Health Narcotics Oral and Maxillofacial Surgery Otorhinolaryngology Pain Patients Plastic Surgery Self evaluation Statistical analysis Surgery |
| title | Comparative Evaluation of Pre-Emptive Analgesic Efficacy of Intramuscular Ketorolac Versus Tramadol Following Third Molar Surgery |
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