1,2,3,4-Diepoxybutane-Induced DNA–Protein Cross-Linking in Human Fibrosarcoma (HT1080) Cells

1,2,3,4-Diepoxybutane (DEB) is the key carcinogenic metabolite of 1,3-butadiene (BD), an important industrial and environmental chemical present in urban air and in cigarette smoke. DEB is a genotoxic bis-electrophile capable of cross-linking cellular biomolecules to form DNA–DNA and DNA–protein cro...

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Veröffentlicht in:	Journal of proteome research 2013-05, Vol.12 (5), p.2151-2164
Hauptverfasser:	Gherezghiher, Teshome B, Ming, Xun, Villalta, Peter W, Campbell, Colin, Tretyakova, Natalia Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Cell Line, Tumor Cell Survival - drug effects Cross-Linking Reagents - chemistry Cross-Linking Reagents - pharmacology DNA - chemistry DNA - metabolism DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism Epoxy Compounds - chemistry Epoxy Compounds - pharmacology Fibrosarcoma Genome, Human Humans Molecular Sequence Annotation Protein Binding Proteome - chemistry Proteome - metabolism Proteomics Spectrometry, Mass, Electrospray Ionization Tandem Mass Spectrometry
Online-Zugang:	Volltext
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