Hydrogen sulfide deficiency and diabetic renal remodeling: role of matrix metalloproteinase-9

Matrix metalloproteinase-9 (MMP-9) causes adverse remodeling, whereas hydrogen sulfide (H2S) rescues organs in vascular diseases. The involvement of MMP-9 and H2S in diabetic renovascular remodeling is, however, not well characterized. We determined whether MMP-9 regulates H2S generation and whether...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 2013-06, Vol.304 (12), p.E1365-E1378
Hauptverfasser:	Kundu, Sourav, Pushpakumar, Sathnur B, Tyagi, Aaron, Coley, Denise, Sen, Utpal
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Diabetes Diabetic Nephropathies - genetics Diabetic Nephropathies - metabolism Dizocilpine Maleate - pharmacology Endothelial Cells - cytology Enzymes Excitatory Amino Acid Antagonists - pharmacology Glycosuria, Renal - genetics Glycosuria, Renal - metabolism Hydrogen sulfide Hydrogen Sulfide - metabolism Kidney Glomerulus - blood supply Kidney Glomerulus - cytology Kidney Tubules, Proximal - blood supply Kidney Tubules, Proximal - cytology Kidneys Matrix Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Mice Mice, Inbred C57BL Mice, Knockout Molecules Proteins Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - genetics Receptors, N-Methyl-D-Aspartate - metabolism RNA, Small Interfering - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!