Exacerbated egg‐induced immunopathology in murine Schistosoma mansoni infection is primarily mediated by IL‐17 and restrained by IFN‐γ

In schistosomiasis, the severity of CD4+ T‐cell‐mediated hepatic granulomatous inflammation against parasite eggs varies considerably in humans and among mouse strains. In C57BL/6 mice, pronounced exacerbation of immunopathology induced by immunization with schistosome egg Ag in CFA (SEA/CFA) substa...

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Veröffentlicht in:	European journal of immunology 2011-09, Vol.41 (9), p.2677-2687
Hauptverfasser:	Rutitzky, Laura I., Stadecker, Miguel J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD4+ T cells Cytokines Disease Progression Egg Proteins - immunology Eggs Granuloma Host/pathogen interactions Immunization Inflammation Interferon-gamma - genetics Interferon-gamma - immunology Interferon-gamma - metabolism Interleukin-17 - genetics Interleukin-17 - immunology Interleukin-17 - metabolism Liver - pathology Mice Mice, Inbred C57BL Mice, Inbred CBA Mice, Knockout Schistosoma mansoni - immunology Schistosoma mansoni - pathogenicity Schistosomiasis mansoni - immunology Schistosomiasis mansoni - physiopathology Species Specificity Th1 Cells - immunology Th1 Cells - metabolism Th1 Cells - parasitology Th1 Cells - pathology Th17 Cells - immunology Th17 Cells - metabolism Th17 Cells - parasitology Th17 Cells - pathology
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