A minocycline derivative reduces nerve injury-induced allodynia, LPS-induced prostaglandin E2 microglial production and signaling via toll-like receptors 2 and 4

•12S-Hydroxy-1,12-pyrazolinominocycline (PMIN) is a non-antibacterial tetracycline.•PMIN or minocycline partially reverses nerve injury-induced allodynia in mice.•PMIN or minocycline reduces LPS-induced PGE2 production by rat microglial cells.•PMIN or minocycline inhibits signaling via human TLR2 an...

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Veröffentlicht in:	Neuroscience letters 2013-05, Vol.543, p.157-162
Hauptverfasser:	Bastos, Leandro F.S., Godin, Adriana M., Zhang, Yingning, Jarussophon, Suwatchai, Ferreira, Bruno C.S., Machado, Renes R., Maier, Steven F., Konishi, Yasuo, de Freitas, Rossimiriam P., Fiebich, Bernd L., Watkins, Linda R., Coelho, Márcio M., Moraes, Márcio F.D.
Format:	Artikel
Sprache:	eng
Schlagworte:	12S-Hydroxy-1,12-pyrazolinominocycline Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Cells, Cultured Chemically modified tetracycline Dinoprostone - biosynthesis Female Humans Hyperalgesia - drug therapy Hyperalgesia - physiopathology Lipopolysaccharides - pharmacology Mice Mice, Inbred C57BL Microglia - drug effects Microglia - metabolism Minocycline - pharmacology Minocycline - therapeutic use Neuralgia - drug therapy Neuralgia - physiopathology Neuropathic pain PGE2 Physical Stimulation Rats Rats, Wistar Sciatic Nerve - injuries Sciatic Nerve - physiopathology Signal Transduction TLR2 TLR4 Toll-Like Receptor 2 - metabolism Toll-Like Receptor 4 - metabolism Touch
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