The Hippo pathway polarizes the actin cytoskeleton during collective migration of Drosophila border cells

Collective migration of Drosophila border cells depends on a dynamic actin cytoskeleton that is highly polarized such that it concentrates around the outer rim of the migrating cluster of cells. How the actin cytoskeleton becomes polarized in these cells to enable collective movement remains unknown...

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Veröffentlicht in:	The Journal of cell biology 2013-06, Vol.201 (6), p.875-885
Hauptverfasser:	Lucas, Eliana P, Khanal, Ichha, Gaspar, Pedro, Fletcher, Georgina C, Polesello, Cedric, Tapon, Nicolas, Thompson, Barry J
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Capping Proteins - metabolism Actin Cytoskeleton - metabolism Actins - metabolism Animals Animals, Genetically Modified Cell adhesion & migration Cell Movement - physiology Cell Polarity - physiology Cytoskeleton DNA-Binding Proteins - metabolism Drosophila melanogaster - cytology Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Drosophila Proteins - metabolism Feedback, Physiological - physiology Female Green Fluorescent Proteins - genetics Insects Intracellular Signaling Peptides and Proteins - metabolism Male Membranes Nuclear Proteins - metabolism Phosphorylation Phosphorylation - physiology Polymerization Protein Kinases - metabolism Protein Serine-Threonine Kinases - metabolism Signal Transduction - physiology Trans-Activators - metabolism Transgenes - physiology YAP-Signaling Proteins
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