Mechanisms underlying helper T-cell plasticity: Implications for immune-mediated disease

CD4 helper T cells are critical for proper immune cell homeostasis and host defense but are also major contributors to immune and inflammatory disease. Arising from a simple biphasic model of differentiation (ie, TH 1 and TH 2 cells). A bewildering number of fates seem possible for helper T cells. T...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2013-05, Vol.131 (5), p.1276-1287
Hauptverfasser:	Hirahara, Kiyoshi, MD, PhD, Poholek, Amanda, PhD, Vahedi, Golnaz, PhD, Laurence, Arian, PhD, MRCP, FRCPath, Kanno, Yuka, MD, PhD, Milner, Joshua D., MD, O’Shea, John J., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	allergic disease Allergy and Immunology Asthma Binding sites Biological and medical sciences Biology Chronic obstructive pulmonary disease, asthma Cytokines - biosynthesis Cytokines - genetics Deoxyribonucleic acid Disease DNA Epigenetics Fundamental and applied biological sciences. Psychology Fundamental immunology Gene expression Gene Expression Regulation - immunology Genomes histone modification Humans Immune system Immune System Diseases - etiology Immune System Diseases - immunology Immune System Diseases - pathology Immunopathology Influence Kinases Ligands Lymphocytes Medical sciences Metabolism Models, Immunological Mutation Pneumology Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Studies T-cell plasticity T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - metabolism T-Lymphocytes, Helper-Inducer - pathology therapy Transcription factors
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