Topical Administration of Manuka Oil Prevents UV-B Irradiation-Induced Cutaneous Photoaging in Mice
Manuka tree is indigenous to New Zealand, and its essential oil has been used as a traditional medicine to treat wounds, fever, and pain. Although there is a growing interest in the use of manuka oil for antiaging skin care products, little is known about its bioactivity. Solar ultraviolet (UV) radi...
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| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2013-01, Vol.2013 (2013), p.1-10 |
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| creator | Kwon, Oh Sook Jung, Seung Hee Yang, Beom Seok |
| description | Manuka tree is indigenous to New Zealand, and its essential oil has been used as a traditional medicine to treat wounds, fever, and pain. Although there is a growing interest in the use of manuka oil for antiaging skin care products, little is known about its bioactivity. Solar ultraviolet (UV) radiation is the primary environmental factor causing skin damage and consequently premature aging. Therefore, we evaluated manuka oil for its effects against photoaging in UV-B-irradiated hairless mice. Topical application of manuka oil suppressed the UV-B-induced increase in skin thickness and wrinkle grading in a dose-dependent manner. Application of 10% manuka oil reduced the average length, depth, and % area of wrinkles significantly, and this was correlated with inhibition of loss of collagen fiber content and epidermal hyperplasia. Furthermore, we observed that manuka oil could suppress UV-B-induced skin inflammation by inhibiting the production of inflammatory cytokines. Taken together, this study provides evidence that manuka oil indeed possesses antiphotoaging activity, and this is associated with its inhibitory activity against skin inflammation induced by UV irradiation. |
| doi_str_mv | 10.1155/2013/930857 |
| format | Article |
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Although there is a growing interest in the use of manuka oil for antiaging skin care products, little is known about its bioactivity. Solar ultraviolet (UV) radiation is the primary environmental factor causing skin damage and consequently premature aging. Therefore, we evaluated manuka oil for its effects against photoaging in UV-B-irradiated hairless mice. Topical application of manuka oil suppressed the UV-B-induced increase in skin thickness and wrinkle grading in a dose-dependent manner. Application of 10% manuka oil reduced the average length, depth, and % area of wrinkles significantly, and this was correlated with inhibition of loss of collagen fiber content and epidermal hyperplasia. Furthermore, we observed that manuka oil could suppress UV-B-induced skin inflammation by inhibiting the production of inflammatory cytokines. Taken together, this study provides evidence that manuka oil indeed possesses antiphotoaging activity, and this is associated with its inhibitory activity against skin inflammation induced by UV irradiation.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2013/930857</identifier><identifier>PMID: 23762170</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Aging ; Antioxidants ; Biological activity ; Cancer ; Collagen ; Cytokines ; Dermatology ; Drug dosages ; Environmental factors ; Essential oils ; Experiments ; Fever ; Free radicals ; Hairless ; Hyperplasia ; Inflammation ; Irradiation ; Kinases ; Laboratory animals ; Pain ; Skin ; Topical application ; Tumor necrosis factor-TNF ; Ultraviolet radiation</subject><ispartof>Evidence-based complementary and alternative medicine, 2013-01, Vol.2013 (2013), p.1-10</ispartof><rights>Copyright © 2013 Oh Sook Kwon et al.</rights><rights>Copyright © 2013 Oh Sook Kwon et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2013 Oh Sook Kwon et al. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-664508827a8c7ebee5eda569f2a2552e805c86aaa90fdeb6b4affab2da201d93</citedby><cites>FETCH-LOGICAL-c466t-664508827a8c7ebee5eda569f2a2552e805c86aaa90fdeb6b4affab2da201d93</cites><orcidid>0000-0001-5387-7752</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677636/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677636/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23762170$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Oh, Ki-Wan</contributor><creatorcontrib>Kwon, Oh Sook</creatorcontrib><creatorcontrib>Jung, Seung Hee</creatorcontrib><creatorcontrib>Yang, Beom Seok</creatorcontrib><title>Topical Administration of Manuka Oil Prevents UV-B Irradiation-Induced Cutaneous Photoaging in Mice</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Manuka tree is indigenous to New Zealand, and its essential oil has been used as a traditional medicine to treat wounds, fever, and pain. 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Taken together, this study provides evidence that manuka oil indeed possesses antiphotoaging activity, and this is associated with its inhibitory activity against skin inflammation induced by UV irradiation.</description><subject>Aging</subject><subject>Antioxidants</subject><subject>Biological activity</subject><subject>Cancer</subject><subject>Collagen</subject><subject>Cytokines</subject><subject>Dermatology</subject><subject>Drug dosages</subject><subject>Environmental factors</subject><subject>Essential oils</subject><subject>Experiments</subject><subject>Fever</subject><subject>Free radicals</subject><subject>Hairless</subject><subject>Hyperplasia</subject><subject>Inflammation</subject><subject>Irradiation</subject><subject>Kinases</subject><subject>Laboratory animals</subject><subject>Pain</subject><subject>Skin</subject><subject>Topical application</subject><subject>Tumor necrosis factor-TNF</subject><subject>Ultraviolet radiation</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0c9rFDEUB_Agiv2hJ89KwIsoY5PM5MdchLr4Y6GlPaziLbxJMrups8k2mWnxvzd16qJeJIcE8uHx3vsi9IySt5RyfsIIrU_amiguH6BDKhtaNUyph_u3_HaAjnK-IoS1UsrH6IDVUjAqySEyq7jzBgZ8arc--DwmGH0MOPb4HML0HfCFH_BlcjcujBl_-Vq9x8uUwPpfrloGOxln8WIaIbg4ZXy5iWOEtQ9r7AM-98Y9QY96GLJ7en8fo9XHD6vF5-rs4tNycXpWmUaIsRKi4UQpJkEZ6TrnuLPARdszYJwzpwg3SgBAS3rrOtE10PfQMQtlA7atj9G7uexu6rbOmtJwgkHvkt9C-qEjeP33T_AbvY43uhZSilqUAq_uC6R4Pbk86q3Pxg3DPJmmBapyqCr05T_0Kk4plOl0WbriqqklKerNrEyKOSfX75uhRN9lp--y03N2Rb_4s_-9_R1WAa9nsPHBwq3_T7XnM3aFuB72mJOWEln_BFrNrAI</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Kwon, Oh Sook</creator><creator>Jung, Seung Hee</creator><creator>Yang, Beom Seok</creator><general>Hindawi Puplishing Corporation</general><general>Hindawi Publishing Corporation</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5387-7752</orcidid></search><sort><creationdate>20130101</creationdate><title>Topical Administration of Manuka Oil Prevents UV-B Irradiation-Induced Cutaneous Photoaging in Mice</title><author>Kwon, Oh Sook ; 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Although there is a growing interest in the use of manuka oil for antiaging skin care products, little is known about its bioactivity. Solar ultraviolet (UV) radiation is the primary environmental factor causing skin damage and consequently premature aging. Therefore, we evaluated manuka oil for its effects against photoaging in UV-B-irradiated hairless mice. Topical application of manuka oil suppressed the UV-B-induced increase in skin thickness and wrinkle grading in a dose-dependent manner. Application of 10% manuka oil reduced the average length, depth, and % area of wrinkles significantly, and this was correlated with inhibition of loss of collagen fiber content and epidermal hyperplasia. Furthermore, we observed that manuka oil could suppress UV-B-induced skin inflammation by inhibiting the production of inflammatory cytokines. Taken together, this study provides evidence that manuka oil indeed possesses antiphotoaging activity, and this is associated with its inhibitory activity against skin inflammation induced by UV irradiation.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>23762170</pmid><doi>10.1155/2013/930857</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-5387-7752</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library Open Access; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Aging Antioxidants Biological activity Cancer Collagen Cytokines Dermatology Drug dosages Environmental factors Essential oils Experiments Fever Free radicals Hairless Hyperplasia Inflammation Irradiation Kinases Laboratory animals Pain Skin Topical application Tumor necrosis factor-TNF Ultraviolet radiation |
| title | Topical Administration of Manuka Oil Prevents UV-B Irradiation-Induced Cutaneous Photoaging in Mice |
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