Identification of novel small molecules that elevate Klotho expression

The absence of Klotho (KL) from mice causes the development of disorders associated with human aging and decreased longevity, whereas increased expression prolongs lifespan. With age, KL protein levels decrease, and keeping levels consistent may promote healthier aging and be disease-modifying. Usin...

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Veröffentlicht in:	Biochemical journal 2012-01, Vol.441 (1), p.453-461
Hauptverfasser:	King, Gwendalyn D, Chen, CiDi, Huang, Mickey M, Zeldich, Ella, Brazee, Patricia L, Schuman, Eli R, Robin, Maxime, Cuny, Gregory D, Glicksman, Marcie A, Abraham, Carmela R
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - physiology Animals Cell Line Cloning, Molecular Drug Screening Assays, Antitumor Fibroblast Growth Factors - pharmacology Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Glucuronidase - genetics Glucuronidase - metabolism Kidney - cytology Mice Opossums Rats
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