Reoxygenation of Hypoxic Glioblastoma Multiforme Cells Potentiates the Killing Effect of an Interleukin-13-Based Cytotoxin

Purpose: Hypoxia is a cause for resistance to cancer therapies. Molecularly targeted recombinant cytotoxins have shown clinical efficacy in the treatment of patients with primary brain tumors, glioblastoma multiforme, but it is not known whether hypoxia influences their antitumor effect. Experimenta...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical cancer research 2009-01, Vol.15 (1), p.160-168
Hauptverfasser:	Liu, Tie Fu, Cai, Jiaozhong, Gibo, Denise M, Debinski, Waldemar
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain Neoplasms - metabolism Brain Neoplasms - therapy Cell Hypoxia Cell Line, Tumor Cytotoxins - pharmacology Diphtheria Toxin - pharmacology furin Furin - analysis Glioblastoma - metabolism Glioblastoma - therapy glioblastoma multiforme Humans hypoxia IL-13Rα2 Immunotoxins - pharmacology Interleukin-13 Interleukin-13 Receptor alpha2 Subunit - metabolism Oxygen - pharmacology recombinant cytotoxin
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!