Inflammatory cytokines induce NOTCH signaling in nucleus pulposus cells: implications in intervertebral disc degeneration

The objective of the study was to investigate how inflammatory cytokines, IL-1β, and TNF-α control NOTCH signaling activity in nucleus pulposus (NP) cells. An increase in expression of selective NOTCH receptors (NOTCH1 and -2), ligand (JAGGED2), and target genes (HES1, HEY1, and HEY2) was observed i...

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Veröffentlicht in:	The Journal of biological chemistry 2013-06, Vol.288 (23), p.16761-16774
Hauptverfasser:	Wang, Hua, Tian, Ye, Wang, Jianru, Phillips, Kate L E, Binch, Abbie L A, Dunn, Sara, Cross, Alison, Chiverton, Neil, Zheng, Zhaomin, Shapiro, Irving M, Le Maitre, Christine L, Risbud, Makarand V
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animals Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Line Female Glycobiology and Extracellular Matrices Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Interleukin-1beta - genetics Interleukin-1beta - metabolism Intervertebral Disc - metabolism Intervertebral Disc - pathology Intervertebral Disc Degeneration - genetics Intervertebral Disc Degeneration - metabolism Intervertebral Disc Degeneration - pathology Male MAP Kinase Signaling System Middle Aged Promoter Regions, Genetic - genetics Rats Receptor, Notch1 - genetics Receptor, Notch1 - metabolism Receptor, Notch2 - genetics Receptor, Notch2 - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism Transcription Factor HES-1 Transcription Factor RelA - genetics Transcription Factor RelA - metabolism Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism
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