IL28B expression depends on a novel TT/-G polymorphism which improves HCV clearance prediction

Approximately 3% of the world population is chronically infected with the hepatitis C virus (HCV), with potential development of cirrhosis and hepatocellular carcinoma. Despite the availability of new antiviral agents, treatment remains suboptimal. Genome-wide association studies (GWAS) identified r...

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Veröffentlicht in:	The Journal of experimental medicine 2013-06, Vol.210 (6), p.1109-1116
Hauptverfasser:	Bibert, Stéphanie, Roger, Thierry, Calandra, Thierry, Bochud, Murielle, Cerny, Andreas, Semmo, Nasser, Duong, François H T, Gerlach, Tilman, Malinverni, Raffaele, Moradpour, Darius, Negro, Francesco, Müllhaupt, Beat, Bochud, Pierre-Yves
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Brief Definitive Report Chemokine CXCL10 - biosynthesis Chemokine CXCL10 - genetics Chemokine CXCL10 - immunology Genotype Hepacivirus - physiology Hepatitis C virus Hepatitis C, Chronic - genetics Hepatitis C, Chronic - immunology Hepatitis C, Chronic - virology Humans Interferon-gamma - biosynthesis Interferon-gamma - genetics Interferon-gamma - immunology Interferons Interleukins - biosynthesis Interleukins - genetics Interleukins - immunology Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - virology Polymorphism, Genetic RNA, Messenger - genetics
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