Enhanced 4-Hydroxynonenal Resistance in KEAP1 Silenced Human Colon Cancer Cells

Nuclear factor erythroid 2-related factor 2 (NRF2) is the transcription factor that regulates an array of antioxidant/detoxifying genes for cellular defense. The conformational changes of Kelch-like ECH-associated protein 1 (KEAP1), a cytosolic repressor protein of NRF2, by various stimuli result in...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2013-01, Vol.2013 (2013), p.1-16
Hauptverfasser:	Jung, Kyeong-Ah, Kwak, Mi-Kyoung
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde Reductase - metabolism Aldehydes - metabolism Aldo-Keto Reductases Cell Death - drug effects Cell Survival - drug effects Cell Survival - genetics Colonic Neoplasms - genetics Colonic Neoplasms - pathology DNA Adducts - metabolism Gene Expression Regulation, Neoplastic - drug effects Gene Knockdown Techniques Gene Silencing - drug effects HCT116 Cells HEK293 Cells HT29 Cells Humans Hydrogen Peroxide - pharmacology Intracellular Signaling Peptides and Proteins - antagonists & inhibitors Intracellular Signaling Peptides and Proteins - metabolism Kelch-Like ECH-Associated Protein 1 NF-E2-Related Factor 2 - metabolism Oxidative Stress - drug effects Oxidative Stress - genetics Vitamin K 3 - pharmacology
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