Diagnostic value of immunoglobulin G antibodies against Candida enolase and fructose-bisphosphate aldolase for candidemia

The yeast Candida is one of the most frequent pathogens isolated from bloodstream infections and is associated with significant morbidity and mortality. Problems with clinical and microbiological diagnosis of invasive candidiasis (IC) have prompted the development of non-culture-based laboratory met...

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Veröffentlicht in:BMC infectious diseases 2013-05, Vol.13 (1), p.253-253, Article 253
Hauptverfasser: Li, Fang-Qiu, Ma, Chun-Fang, Shi, Li-Ning, Lu, Jing-Fen, Wang, Ying, Huang, Mei, Kong, Qian-Qian
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container_title BMC infectious diseases
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creator Li, Fang-Qiu
Ma, Chun-Fang
Shi, Li-Ning
Lu, Jing-Fen
Wang, Ying
Huang, Mei
Kong, Qian-Qian
description The yeast Candida is one of the most frequent pathogens isolated from bloodstream infections and is associated with significant morbidity and mortality. Problems with clinical and microbiological diagnosis of invasive candidiasis (IC) have prompted the development of non-culture-based laboratory methods. Previous reports suggest that serological detection of antibodies might be useful for diagnosing systemic candidiasis. Diagnosis of IC using antibodies against recombinant Candida albicans enolase (Eno) and fructose-bisphosphate aldolase (Fba1) was evaluated. Using recombinant Eno and Fba1 as coating antigens, enzyme-linked immunosorbent assays (ELISAs) were used to analyze sera from patients with candidemia (n = 101), Candida colonization (n = 50), bacteremia (n = 84), invasive aspergillosis (n = 40); and from healthy controls (n = 200). The results demonstrated that ELISA detection of anti-Eno and anti-Fba1 IgG distinguished IC from other pathogenic infections in patients and healthy individuals. The sensitivity, specificity, and positive and negative predictive values were 72.3%, 94.7%, 78.5% and 93% for anti-Eno, and 87.1%, 92.8%, 76.5% and 96.4% for anti-Fba1 antibodies, respectively. Combining these two tests improved sensitivity up to 90.1% and negative predictive value up to 97.1%, with specificity and positive predictive values of 90.6% and 72.2%. The tests were specific to the Candida genus and antibody titers were higher for candidemia patients than for controls. Positive antibody tests were obtained before blood culture results for 42.2% of patients for anti-Eno and 51.1% for anti-Fba1. These data suggest that tests that detect IgG antibodies against Candida enolase and fructose-bisphosphate aldolase, especially when used in combination, could be a powerful tool for diagnosing IC.
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Problems with clinical and microbiological diagnosis of invasive candidiasis (IC) have prompted the development of non-culture-based laboratory methods. Previous reports suggest that serological detection of antibodies might be useful for diagnosing systemic candidiasis. Diagnosis of IC using antibodies against recombinant Candida albicans enolase (Eno) and fructose-bisphosphate aldolase (Fba1) was evaluated. Using recombinant Eno and Fba1 as coating antigens, enzyme-linked immunosorbent assays (ELISAs) were used to analyze sera from patients with candidemia (n = 101), Candida colonization (n = 50), bacteremia (n = 84), invasive aspergillosis (n = 40); and from healthy controls (n = 200). The results demonstrated that ELISA detection of anti-Eno and anti-Fba1 IgG distinguished IC from other pathogenic infections in patients and healthy individuals. The sensitivity, specificity, and positive and negative predictive values were 72.3%, 94.7%, 78.5% and 93% for anti-Eno, and 87.1%, 92.8%, 76.5% and 96.4% for anti-Fba1 antibodies, respectively. Combining these two tests improved sensitivity up to 90.1% and negative predictive value up to 97.1%, with specificity and positive predictive values of 90.6% and 72.2%. The tests were specific to the Candida genus and antibody titers were higher for candidemia patients than for controls. Positive antibody tests were obtained before blood culture results for 42.2% of patients for anti-Eno and 51.1% for anti-Fba1. These data suggest that tests that detect IgG antibodies against Candida enolase and fructose-bisphosphate aldolase, especially when used in combination, could be a powerful tool for diagnosing IC.</description><identifier>ISSN: 1471-2334</identifier><identifier>EISSN: 1471-2334</identifier><identifier>DOI: 10.1186/1471-2334-13-253</identifier><identifier>PMID: 23725337</identifier><language>eng</language><publisher>England: BioMed Central</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Antibodies, Fungal - blood ; Antigens, Fungal - immunology ; Aspergillus ; Candida - enzymology ; Candida - immunology ; Candida - isolation &amp; purification ; Candida albicans ; Candidemia - diagnosis ; Candidemia - immunology ; Case-Control Studies ; Catheters ; Cohort Studies ; Enzyme-Linked Immunosorbent Assay - methods ; Female ; Fructose-Bisphosphate Aldolase - immunology ; Fungal Proteins - immunology ; Hospitalization ; Hospitals ; Humans ; Immunoglobulin G - blood ; Infections ; Male ; Middle Aged ; Molecular biology ; Mortality ; Patients ; Phosphopyruvate Hydratase - immunology ; Reproducibility of Results ; Sensitivity and Specificity ; Serologic Tests - methods ; Statistics, Nonparametric</subject><ispartof>BMC infectious diseases, 2013-05, Vol.13 (1), p.253-253, Article 253</ispartof><rights>2013 Li et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2013 Li et al.; licensee BioMed Central Ltd. 2013 Li et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b583t-59656fb62136002ea5fa46bd291a90e829a3db998a454b583cab064df11f2c653</citedby><cites>FETCH-LOGICAL-b583t-59656fb62136002ea5fa46bd291a90e829a3db998a454b583cab064df11f2c653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673856/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673856/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23725337$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Fang-Qiu</creatorcontrib><creatorcontrib>Ma, Chun-Fang</creatorcontrib><creatorcontrib>Shi, Li-Ning</creatorcontrib><creatorcontrib>Lu, Jing-Fen</creatorcontrib><creatorcontrib>Wang, Ying</creatorcontrib><creatorcontrib>Huang, Mei</creatorcontrib><creatorcontrib>Kong, Qian-Qian</creatorcontrib><title>Diagnostic value of immunoglobulin G antibodies against Candida enolase and fructose-bisphosphate aldolase for candidemia</title><title>BMC infectious diseases</title><addtitle>BMC Infect Dis</addtitle><description>The yeast Candida is one of the most frequent pathogens isolated from bloodstream infections and is associated with significant morbidity and mortality. Problems with clinical and microbiological diagnosis of invasive candidiasis (IC) have prompted the development of non-culture-based laboratory methods. Previous reports suggest that serological detection of antibodies might be useful for diagnosing systemic candidiasis. Diagnosis of IC using antibodies against recombinant Candida albicans enolase (Eno) and fructose-bisphosphate aldolase (Fba1) was evaluated. Using recombinant Eno and Fba1 as coating antigens, enzyme-linked immunosorbent assays (ELISAs) were used to analyze sera from patients with candidemia (n = 101), Candida colonization (n = 50), bacteremia (n = 84), invasive aspergillosis (n = 40); and from healthy controls (n = 200). The results demonstrated that ELISA detection of anti-Eno and anti-Fba1 IgG distinguished IC from other pathogenic infections in patients and healthy individuals. 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Problems with clinical and microbiological diagnosis of invasive candidiasis (IC) have prompted the development of non-culture-based laboratory methods. Previous reports suggest that serological detection of antibodies might be useful for diagnosing systemic candidiasis. Diagnosis of IC using antibodies against recombinant Candida albicans enolase (Eno) and fructose-bisphosphate aldolase (Fba1) was evaluated. Using recombinant Eno and Fba1 as coating antigens, enzyme-linked immunosorbent assays (ELISAs) were used to analyze sera from patients with candidemia (n = 101), Candida colonization (n = 50), bacteremia (n = 84), invasive aspergillosis (n = 40); and from healthy controls (n = 200). The results demonstrated that ELISA detection of anti-Eno and anti-Fba1 IgG distinguished IC from other pathogenic infections in patients and healthy individuals. The sensitivity, specificity, and positive and negative predictive values were 72.3%, 94.7%, 78.5% and 93% for anti-Eno, and 87.1%, 92.8%, 76.5% and 96.4% for anti-Fba1 antibodies, respectively. Combining these two tests improved sensitivity up to 90.1% and negative predictive value up to 97.1%, with specificity and positive predictive values of 90.6% and 72.2%. The tests were specific to the Candida genus and antibody titers were higher for candidemia patients than for controls. Positive antibody tests were obtained before blood culture results for 42.2% of patients for anti-Eno and 51.1% for anti-Fba1. These data suggest that tests that detect IgG antibodies against Candida enolase and fructose-bisphosphate aldolase, especially when used in combination, could be a powerful tool for diagnosing IC.</abstract><cop>England</cop><pub>BioMed Central</pub><pmid>23725337</pmid><doi>10.1186/1471-2334-13-253</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
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subjects Adult
Aged
Aged, 80 and over
Antibodies, Fungal - blood
Antigens, Fungal - immunology
Aspergillus
Candida - enzymology
Candida - immunology
Candida - isolation & purification
Candida albicans
Candidemia - diagnosis
Candidemia - immunology
Case-Control Studies
Catheters
Cohort Studies
Enzyme-Linked Immunosorbent Assay - methods
Female
Fructose-Bisphosphate Aldolase - immunology
Fungal Proteins - immunology
Hospitalization
Hospitals
Humans
Immunoglobulin G - blood
Infections
Male
Middle Aged
Molecular biology
Mortality
Patients
Phosphopyruvate Hydratase - immunology
Reproducibility of Results
Sensitivity and Specificity
Serologic Tests - methods
Statistics, Nonparametric
title Diagnostic value of immunoglobulin G antibodies against Candida enolase and fructose-bisphosphate aldolase for candidemia
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