Antigen receptor control of amino acid transport coordinates the metabolic re-programming that is essential for T cell differentiation

T lymphocytes regulate nutrient uptake to meet the metabolic demands of immune activation. The present study shows that the intracellular supply of large neutral amino acids (LNAAs) in T cells is regulated by pathogen and the T cell antigen receptor (TCR). A single System L transporter, Slc7a5, medi...

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Veröffentlicht in:	Nature immunology 2013-03, Vol.14 (5), p.500-508
Hauptverfasser:	Sinclair, Linda V., Rolf, Julia, Emslie, Elizabeth, Shi, Yun-Bo, Taylor, Peter M., Cantrell, Doreen A.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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