Multiple Steps to Activate FAK’s Kinase Domain: Adaptation to Confined Environments?

Protein kinases regulate cell signaling by phosphorylating their substrates in response to environment-specific stimuli. Using molecular dynamics, we studied the catalytically active and inactive conformations of the kinase domain of the focal adhesion kinase (FAK), which are distinguished by displa...

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Veröffentlicht in:	Biophysical journal 2013-06, Vol.104 (11), p.2521-2529
Hauptverfasser:	Herzog, Florian A., Vogel, Viola
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological Adenosine triphosphatase adenosine triphosphate Adenosine Triphosphate - metabolism adhesion Binding sites Catalytic Domain Enzyme Activation Enzyme kinetics Focal Adhesion Protein-Tyrosine Kinases - chemistry Focal Adhesion Protein-Tyrosine Kinases - genetics Focal Adhesion Protein-Tyrosine Kinases - metabolism Kinases Kinetics Magnesium - metabolism molecular dynamics Molecular Dynamics Simulation Mutation Phosphorylation protein kinases Protein Structure, Tertiary Proteins and Nucleic Acids
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