Unraveling the 'TGF-β paradox' one metastamir at a time
Transforming growth factor beta (TGF-β) has received noteworthy attention in the recent past due to its unique characteristic of functionally switching roles from tumor suppressor to metastasis promoter. To uncover the black box surrounding the mechanisms of TGF-β, Taylor and colleagues performed gl...
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| Veröffentlicht in: | Breast cancer research : BCR 2013-02, Vol.15 (1), p.305-305, Article 305 |
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| container_title | Breast cancer research : BCR |
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| creator | Welch, Danny R Hurst, Douglas R |
| description | Transforming growth factor beta (TGF-β) has received noteworthy attention in the recent past due to its unique characteristic of functionally switching roles from tumor suppressor to metastasis promoter. To uncover the black box surrounding the mechanisms of TGF-β, Taylor and colleagues performed global miRNA expression analyses using a murine mammary carcinoma progression model. They discovered multiple miRNA regulated by TGF-β and matrix stiffness. Focusing on miR-181a, they uncovered an intricate pathway regulating breast cancer metastasis that sheds new insight into metastasis regulation that may prove useful in clinical settings. |
| doi_str_mv | 10.1186/bcr3383 |
| format | Article |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access; Springer Nature OA Free Journals |
| subjects | Animals Breast Neoplasms - genetics Breast Neoplasms - pathology Cell Line, Tumor Female Gene Expression Regulation, Neoplastic Humans Mammary Neoplasms, Animal - genetics Mammary Neoplasms, Animal - pathology Mice MicroRNAs - biosynthesis Transforming Growth Factor beta - biosynthesis Transforming Growth Factor beta - genetics Viewpoint |
| title | Unraveling the 'TGF-β paradox' one metastamir at a time |
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