Rac1 Is Required for Matrix Metalloproteinase 13 Production by Chondrocytes in Response to Fibronectin Fragments

Objective Matrix fragments, including fibronectin (FN) fragments, accumulate during the development of osteoarthritis (OA), stimulating the production of chondrocyte matrix metalloproteinase (MMP). The objective of this study was to determine the role of the small GTPase Rac1 in chondrocyte signalin...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2013-06, Vol.65 (6), p.1561-1568
Hauptverfasser:	Long, David L., Willey, Jeffrey S., Loeser, Richard F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenovirus Cartilage, Articular - enzymology Cells, Cultured Chondrocytes - enzymology Epidermal growth factor Fibronectins - metabolism Humans Immunoblotting Immunohistochemistry Joint surgery Matrix Metalloproteinase 13 - metabolism Osteoarthritis - metabolism Proteins rac1 GTP-Binding Protein - metabolism Real-Time Polymerase Chain Reaction Signal Transduction
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