Assessment of Pain and Itch Behavior in a Mouse Model of Neurofibromatosis Type 1

Abstract Neurofibromatosis type 1 (NF1) is characterized primarily by tumor formation in the nervous system, but patients report other neurological complications including pain and itch. Individuals with NF1 harbor 1 mutated NF1 allele causing heterozygous expression in all of their cells. In mice,...

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Veröffentlicht in:	The journal of pain 2013-06, Vol.14 (6), p.628-637
Hauptverfasser:	O'Brien, Daniel E, Brenner, Daniel S, Gutmann, David H, Gereau, Robert W
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia & Perioperative Care Animals Capsaicin - adverse effects Chloroquine - toxicity Constriction Disease Models, Animal Functional Laterality Histamine - toxicity Hyperalgesia - physiopathology itch Male Mice Mice, Inbred C57BL Mice, Transgenic Neurofibromatosis Neurofibromatosis 1 - complications Neurofibromatosis 1 - genetics Neurofibromatosis 1 - metabolism p-Methoxy-N-methylphenethylamine - toxicity pain Pain - chemically induced Pain - diagnosis Pain - etiology Pain Measurement Pain Medicine Pain Threshold - physiology Pruritus - chemically induced Pruritus - diagnosis Pruritus - etiology Ras-GAP
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