Mucosal Melanoma in the Head and Neck Region: Different Clinical Features and Same Outcome to Cutaneous Melanoma
Mucosal melanoma (MM) in the head and neck (H&N) is relatively rare and behaves in distinct pattern from cutaneous melanoma (CM). We performed this study to define clinical characteristics and outcomes of patients and emphasize MM differences from CM. Forty-one patients with MM located in H&...
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| Veröffentlicht in: | ISRN Dermatology 2013, Vol.2013, p.586915-5 |
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| description | Mucosal melanoma (MM) in the head and neck (H&N) is relatively rare and behaves in distinct pattern from cutaneous melanoma (CM). We performed this study to define clinical characteristics and outcomes of patients and emphasize MM differences from CM. Forty-one patients with MM located in H&N were assessed. 94 CM patients originated from H&N region were also used for comparison. Patients had oral cavity (51%) and sinonasal location (49%).The median age was 60 years and gender distribution was equal. Thirty-two (78%) patients had localized stage, four (10%) patients had regional lymph node metastasis, and five (12%) patients had distant metastasis. The 1- and 5-year overall survival rates were 81% and 58%, respectively. Outcomes were similar between sinonasal and oral cavity patients (P=0.67). Advanced disease was the significant prognostic factor for outcome (P=0.03). MM patients are older (P=0.008) and more diagnosed as a localized disease patients at presentation than those with CM (P=0.06). Overall survival rates were identical in patients with MM and CM (P=0.53). In conclusion, despite different clinical features, outcome was identical in patients with MM and CM located in the H&N region. |
| doi_str_mv | 10.1155/2013/586915 |
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F.</contributor><creatorcontrib>Tas, Faruk ; Keskin, Serkan ; Pasmatzi, E. ; Chao, S.-C. ; Tuzun, Y. ; Val-Bernal, J. F.</creatorcontrib><description>Mucosal melanoma (MM) in the head and neck (H&N) is relatively rare and behaves in distinct pattern from cutaneous melanoma (CM). We performed this study to define clinical characteristics and outcomes of patients and emphasize MM differences from CM. Forty-one patients with MM located in H&N were assessed. 94 CM patients originated from H&N region were also used for comparison. Patients had oral cavity (51%) and sinonasal location (49%).The median age was 60 years and gender distribution was equal. Thirty-two (78%) patients had localized stage, four (10%) patients had regional lymph node metastasis, and five (12%) patients had distant metastasis. The 1- and 5-year overall survival rates were 81% and 58%, respectively. Outcomes were similar between sinonasal and oral cavity patients (P=0.67). Advanced disease was the significant prognostic factor for outcome (P=0.03). MM patients are older (P=0.008) and more diagnosed as a localized disease patients at presentation than those with CM (P=0.06). Overall survival rates were identical in patients with MM and CM (P=0.53). In conclusion, despite different clinical features, outcome was identical in patients with MM and CM located in the H&N region.</description><identifier>ISSN: 2090-4592</identifier><identifier>ISSN: 2090-4606</identifier><identifier>EISSN: 2090-4606</identifier><identifier>DOI: 10.1155/2013/586915</identifier><identifier>PMID: 23762595</identifier><language>eng</language><publisher>Egypt: Hindawi Publishing Corporation</publisher><subject>Age ; Cancer therapies ; Chemotherapy ; Clinical Study ; Disease control ; Melanoma ; Patients ; Radiation therapy ; Surgery ; Tumors</subject><ispartof>ISRN Dermatology, 2013, Vol.2013, p.586915-5</ispartof><rights>Copyright © 2013 Faruk Tas and Serkan Keskin.</rights><rights>Copyright © 2013 Faruk Tas and Serkan Keskin. Faruk Tas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2013 F. Tas and S. Keskin. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2895-aa8e3e708a834da844daed21c37cc401259b869bc89b7489cd4148d1ef0586243</citedby><cites>FETCH-LOGICAL-c2895-aa8e3e708a834da844daed21c37cc401259b869bc89b7489cd4148d1ef0586243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670547/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670547/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,883,4012,27906,27907,27908,53774,53776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23762595$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Pasmatzi, E.</contributor><contributor>Chao, S.-C.</contributor><contributor>Tuzun, Y.</contributor><contributor>Val-Bernal, J. F.</contributor><creatorcontrib>Tas, Faruk</creatorcontrib><creatorcontrib>Keskin, Serkan</creatorcontrib><title>Mucosal Melanoma in the Head and Neck Region: Different Clinical Features and Same Outcome to Cutaneous Melanoma</title><title>ISRN Dermatology</title><addtitle>ISRN Dermatol</addtitle><description>Mucosal melanoma (MM) in the head and neck (H&N) is relatively rare and behaves in distinct pattern from cutaneous melanoma (CM). We performed this study to define clinical characteristics and outcomes of patients and emphasize MM differences from CM. Forty-one patients with MM located in H&N were assessed. 94 CM patients originated from H&N region were also used for comparison. Patients had oral cavity (51%) and sinonasal location (49%).The median age was 60 years and gender distribution was equal. Thirty-two (78%) patients had localized stage, four (10%) patients had regional lymph node metastasis, and five (12%) patients had distant metastasis. The 1- and 5-year overall survival rates were 81% and 58%, respectively. Outcomes were similar between sinonasal and oral cavity patients (P=0.67). Advanced disease was the significant prognostic factor for outcome (P=0.03). MM patients are older (P=0.008) and more diagnosed as a localized disease patients at presentation than those with CM (P=0.06). Overall survival rates were identical in patients with MM and CM (P=0.53). In conclusion, despite different clinical features, outcome was identical in patients with MM and CM located in the H&N region.</description><subject>Age</subject><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>Clinical Study</subject><subject>Disease control</subject><subject>Melanoma</subject><subject>Patients</subject><subject>Radiation therapy</subject><subject>Surgery</subject><subject>Tumors</subject><issn>2090-4592</issn><issn>2090-4606</issn><issn>2090-4606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc1LHTEUxYNYVKwr9xJwI5WnSSaZyXQhlGf9AK3Q1nW4L3PHFzuTvCYzLf3vGzv6sF00i9xAfjmck0PIPmcnnCt1KhgvTpUua642yI5gNZvJkpWbL2dVi22yl9Ijy0sxoapyi2yLoiqFqtUOWd2ONiTo6C124EMP1Hk6LJFeITQUfEM_of1GP-ODC_49PXdtixH9QOed887mhxcIwxgx_YG_QI_0bhxsyHMIdD4O4DGMaa3_lrxpoUu49zx3yf3Fx6_zq9nN3eX1_MPNzApdqxmAxgIrpkEXsgEt84aN4LaorJWMZ_eLnHphdb2opK5tI7nUDceW5d8QstglZ5Pualz02NjsOUJnVtH1EH-ZAM78fePd0jyEH6YoK6ZklQWOngVi-D5iGkzvksWumwIZnkGtGa_qjB7-gz6GMfocz3ApNGOaFSJTxxNlY0gpYrs2w5l5KtM8lWmmMjN98Nr_mn2pLgPvJmDpfAM_3X_VfgOcVqWO</recordid><startdate>2013</startdate><enddate>2013</enddate><creator>Tas, Faruk</creator><creator>Keskin, Serkan</creator><general>Hindawi Publishing Corporation</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2013</creationdate><title>Mucosal Melanoma in the Head and Neck Region: Different Clinical Features and Same Outcome to Cutaneous Melanoma</title><author>Tas, Faruk ; Keskin, Serkan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2895-aa8e3e708a834da844daed21c37cc401259b869bc89b7489cd4148d1ef0586243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Age</topic><topic>Cancer therapies</topic><topic>Chemotherapy</topic><topic>Clinical Study</topic><topic>Disease control</topic><topic>Melanoma</topic><topic>Patients</topic><topic>Radiation therapy</topic><topic>Surgery</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tas, Faruk</creatorcontrib><creatorcontrib>Keskin, Serkan</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>ISRN Dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tas, Faruk</au><au>Keskin, Serkan</au><au>Pasmatzi, E.</au><au>Chao, S.-C.</au><au>Tuzun, Y.</au><au>Val-Bernal, J. F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mucosal Melanoma in the Head and Neck Region: Different Clinical Features and Same Outcome to Cutaneous Melanoma</atitle><jtitle>ISRN Dermatology</jtitle><addtitle>ISRN Dermatol</addtitle><date>2013</date><risdate>2013</risdate><volume>2013</volume><spage>586915</spage><epage>5</epage><pages>586915-5</pages><issn>2090-4592</issn><issn>2090-4606</issn><eissn>2090-4606</eissn><abstract>Mucosal melanoma (MM) in the head and neck (H&N) is relatively rare and behaves in distinct pattern from cutaneous melanoma (CM). We performed this study to define clinical characteristics and outcomes of patients and emphasize MM differences from CM. Forty-one patients with MM located in H&N were assessed. 94 CM patients originated from H&N region were also used for comparison. Patients had oral cavity (51%) and sinonasal location (49%).The median age was 60 years and gender distribution was equal. Thirty-two (78%) patients had localized stage, four (10%) patients had regional lymph node metastasis, and five (12%) patients had distant metastasis. The 1- and 5-year overall survival rates were 81% and 58%, respectively. Outcomes were similar between sinonasal and oral cavity patients (P=0.67). Advanced disease was the significant prognostic factor for outcome (P=0.03). MM patients are older (P=0.008) and more diagnosed as a localized disease patients at presentation than those with CM (P=0.06). Overall survival rates were identical in patients with MM and CM (P=0.53). In conclusion, despite different clinical features, outcome was identical in patients with MM and CM located in the H&N region.</abstract><cop>Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>23762595</pmid><doi>10.1155/2013/586915</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age Cancer therapies Chemotherapy Clinical Study Disease control Melanoma Patients Radiation therapy Surgery Tumors |
| title | Mucosal Melanoma in the Head and Neck Region: Different Clinical Features and Same Outcome to Cutaneous Melanoma |
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