Autoantibodies to MUC1 glycopeptides cannot be used as a screening assay for early detection of breast, ovarian, lung or pancreatic cancer

Background: Autoantibodies have been detected in sera before diagnosis of cancer leading to interest in their potential as screening/early detection biomarkers. As we have found autoantibodies to MUC1 glycopeptides to be elevated in early-stage breast cancer patients, in this study we analysed these...

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Veröffentlicht in:	British journal of cancer 2013-05, Vol.108 (10), p.2045-2055
Hauptverfasser:	Burford, B, Gentry-Maharaj, A, Graham, R, Allen, D, Pedersen, J W, Nudelman, A S, Blixt, O, Fourkala, E O, Bueti, D, Dawnay, A, Ford, J, Desai, R, David, L, Trinder, P, Acres, B, Schwientek, T, Gammerman, A, Reis, C A, Silva, L, Osório, H, Hallett, R, Wandall, H H, Mandel, U, Hollingsworth, M A, Jacobs, I, Fentiman, I, Clausen, H, Taylor-Papadimitriou, J, Menon, U, Burchell, J M
Format:	Artikel
Sprache:	eng
Schlagworte:	692/699/67/1347 692/699/67/2322 692/700/139 Adult Aged Autoantibodies - blood Biological and medical sciences Biomedical and Life Sciences Biomedicine Breast Neoplasms - blood Breast Neoplasms - diagnosis Breast Neoplasms - immunology Cancer Research Carcinoma - blood Carcinoma - diagnosis Carcinoma - immunology Case-Control Studies Cohort Studies Drug Resistance Early Detection of Cancer - methods Epidemiology Female Female genital diseases Glycopeptides - immunology Gynecology. Andrology. Obstetrics Humans Immunoassay Lung Neoplasms - blood Lung Neoplasms - diagnosis Lung Neoplasms - immunology Medical sciences Middle Aged Molecular Diagnostics Molecular Medicine Mucin-1 - immunology Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Oncology Ovarian Neoplasms - blood Ovarian Neoplasms - diagnosis Ovarian Neoplasms - immunology Pancreatic cancer Pancreatic Neoplasms - blood Pancreatic Neoplasms - diagnosis Pancreatic Neoplasms - immunology Tumors
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