μ-Opioid receptor availability in the amygdala is associated with smoking for negative affect relief

Rationale The perception that smoking relieves negative affect contributes to smoking persistence. Endogenous opioid neurotransmission, and the μ-opioid receptor (MOR) in particular, plays a role in affective regulation and is modulated by nicotine. Objectives We examined the relationship of MOR bin...

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Veröffentlicht in:	PSYCHOPHARMACOLOGY 2012-08, Vol.222 (4), p.701-708
Hauptverfasser:	Falcone, Mary, Gold, Allison B., Wileyto, E. Paul, Ray, Riju, Ruparel, Kosha, Newberg, Andrew, Dubroff, Jacob, Logan, Jean, Zubieta, Jon-Kar, Blendy, Julie A., Lerman, Caryn
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute effects Addictive behaviors Adult Adult and adolescent clinical studies Affect - drug effects Affect - physiology affect regulation Amygdala Amygdala - diagnostic imaging Amygdala - metabolism Amygdala - physiopathology Biological and medical sciences Biomedical and Life Sciences Biomedicine Carbon Radioisotopes Cigarette smoking Data processing Double-Blind Method Emotions Female Fentanyl - analogs & derivatives Functional Neuroimaging - methods Functional Neuroimaging - psychology Humans Male Medical sciences Motivation Motivation - physiology mu-Opioid receptor Neurosciences Neurotransmission Nicotine Nicotine - pharmacology Opioid receptors Opioid receptors (type mu) Original Investigation Perception PET (positron emission tomography) Pharmacology/Toxicology Positron emission tomography Positron-Emission Tomography - methods Positron-Emission Tomography - psychology Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Radioligand Assay - methods Radioligand Assay - psychology Receptors, Opioid, mu - metabolism Receptors, Opioid, mu - physiology Smoke Smoking - physiopathology Smoking - psychology smoking motivation Tobacco smoking Tobacco, tobacco smoking Toxicology
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