Intracranial haemorrhage 4 days after receiving thrombolytic therapy in a young woman with myocardial infarction
Intracranial haemorrhage is a known complication after fibrinolytic therapy and occurs usually in the first 24 h. We report a 35-year-old woman who presented with severe central chest pain and she was diagnosed as anterior ST elevation myocardial infarction. She was given fibrinolytic therapy with T...
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description | Intracranial haemorrhage is a known complication after fibrinolytic therapy and occurs usually in the first 24 h. We report a 35-year-old woman who presented with severe central chest pain and she was diagnosed as anterior ST elevation myocardial infarction. She was given fibrinolytic therapy with Tenecteplase. She responded well to the treatment with a decrease in the intensity of chest pain and resolution of the ST segment elevation. She was taken for coronary angiogram the next day, which revealed an occlusion of the left anterior descending (LAD) artery, and stenting of LAD was carried out. Four days later, she developed severe headache, confusion, slurring of speech and right haemiparesis. CT brain revealed intracerebral haemorrhage and she was referred to an neurosurgeon who advised for conservative management. Her condition gradually improved with physiotherapy and was discharged home with no marked functional impairment. |
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We report a 35-year-old woman who presented with severe central chest pain and she was diagnosed as anterior ST elevation myocardial infarction. She was given fibrinolytic therapy with Tenecteplase. She responded well to the treatment with a decrease in the intensity of chest pain and resolution of the ST segment elevation. She was taken for coronary angiogram the next day, which revealed an occlusion of the left anterior descending (LAD) artery, and stenting of LAD was carried out. Four days later, she developed severe headache, confusion, slurring of speech and right haemiparesis. CT brain revealed intracerebral haemorrhage and she was referred to an neurosurgeon who advised for conservative management. Her condition gradually improved with physiotherapy and was discharged home with no marked functional impairment.</description><identifier>ISSN: 1757-790X</identifier><identifier>EISSN: 1757-790X</identifier><identifier>DOI: 10.1136/bcr-2013-009816</identifier><identifier>PMID: 23704457</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Acute coronary syndromes ; Adult ; Cardiovascular disease ; Chest Pain - diagnosis ; Chest Pain - etiology ; Coronary Occlusion - surgery ; Coronary vessels ; Diabetes ; Edema ; Emergency medical care ; Family medical history ; Female ; Fibrinolytic Agents - adverse effects ; Glucose ; Heart attacks ; Hemorrhage ; Humans ; Indian Sub-Continent ; Intracranial Hemorrhages - chemically induced ; Kinases ; Middle East ; Myocardial Infarction - diagnosis ; Myocardial Infarction - drug therapy ; Myocardial Infarction - surgery ; Patients ; Physical therapy ; Risk factors ; Tenecteplase ; Thrombolytic Therapy - adverse effects ; Tissue Plasminogen Activator - adverse effects ; Triglycerides ; Unexpected Outcome (Positive or Negative) Including Adverse Drug Reactions ; Vein & artery diseases ; Womens health</subject><ispartof>BMJ case reports, 2013-05, Vol.2013, p.bcr2013009816</ispartof><rights>2013 BMJ Publishing Group Ltd</rights><rights>Copyright: 2013 2013 BMJ Publishing Group Ltd</rights><rights>2013 BMJ Publishing Group Ltd 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b5116-9ed9f4796fe97da30683789bdf47d10c9d081b5d613d45f140b9d6251d4e19f83</citedby><cites>FETCH-LOGICAL-b5116-9ed9f4796fe97da30683789bdf47d10c9d081b5d613d45f140b9d6251d4e19f83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669972/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669972/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23704457$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ali, Sameera Mohamed</creatorcontrib><creatorcontrib>Rajani, Ali Raza</creatorcontrib><creatorcontrib>Baslaib, Fahad Omar</creatorcontrib><title>Intracranial haemorrhage 4 days after receiving thrombolytic therapy in a young woman with myocardial infarction</title><title>BMJ case reports</title><addtitle>BMJ Case Rep</addtitle><description>Intracranial haemorrhage is a known complication after fibrinolytic therapy and occurs usually in the first 24 h. We report a 35-year-old woman who presented with severe central chest pain and she was diagnosed as anterior ST elevation myocardial infarction. She was given fibrinolytic therapy with Tenecteplase. She responded well to the treatment with a decrease in the intensity of chest pain and resolution of the ST segment elevation. She was taken for coronary angiogram the next day, which revealed an occlusion of the left anterior descending (LAD) artery, and stenting of LAD was carried out. Four days later, she developed severe headache, confusion, slurring of speech and right haemiparesis. CT brain revealed intracerebral haemorrhage and she was referred to an neurosurgeon who advised for conservative management. Her condition gradually improved with physiotherapy and was discharged home with no marked functional impairment.</description><subject>Acute coronary syndromes</subject><subject>Adult</subject><subject>Cardiovascular disease</subject><subject>Chest Pain - diagnosis</subject><subject>Chest Pain - etiology</subject><subject>Coronary Occlusion - surgery</subject><subject>Coronary vessels</subject><subject>Diabetes</subject><subject>Edema</subject><subject>Emergency medical care</subject><subject>Family medical history</subject><subject>Female</subject><subject>Fibrinolytic Agents - adverse effects</subject><subject>Glucose</subject><subject>Heart attacks</subject><subject>Hemorrhage</subject><subject>Humans</subject><subject>Indian Sub-Continent</subject><subject>Intracranial Hemorrhages - chemically induced</subject><subject>Kinases</subject><subject>Middle East</subject><subject>Myocardial Infarction - diagnosis</subject><subject>Myocardial Infarction - drug therapy</subject><subject>Myocardial Infarction - surgery</subject><subject>Patients</subject><subject>Physical therapy</subject><subject>Risk factors</subject><subject>Tenecteplase</subject><subject>Thrombolytic Therapy - adverse effects</subject><subject>Tissue Plasminogen Activator - adverse effects</subject><subject>Triglycerides</subject><subject>Unexpected Outcome (Positive or Negative) Including Adverse Drug Reactions</subject><subject>Vein & artery diseases</subject><subject>Womens health</subject><issn>1757-790X</issn><issn>1757-790X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkU9rFDEYh4MottSee5OAN2Fs3kkmmVwEKVYLBS8KvYVMktnJspOs78y2zM1Lv2g_SbNsLfVkLvnzPvnlDQ8hZ8A-AXB53jmsaga8Yky3IF-RY1CNqpRmN69frI_I6TStWRkcRCv4W3JUc8WEaNQxwas0o3VoU7QbOtgwZsTBrgIVD3_uvV0mavs5IMXgQryNaUXnAfPY5c0yR1c2Ae12oTFRS5e8K_W7PNpE7-I80HHJzqLfR8fUW3RzzOkdedPbzRROn-YT8uvy68-L79X1j29XF1-uq64BkJUOXvdCadkHrbzlTLZctbrz5dADc9qzFrrGS-BeND0I1mkv6wa8CKD7lp-Qz4fc7a4bg3dh_9ON2WIcLS4m22j-raQ4mFW-NVxKrVVdAj48BWD-vQvTbNZ5h6n0bEC1vFaiVlCo8wPlME8Thv75BWBm78kUT2bvyRw8lRvvXzb2zP-1UoCPB6Ab1_9NewTUdZ79</recordid><startdate>20130522</startdate><enddate>20130522</enddate><creator>Ali, Sameera Mohamed</creator><creator>Rajani, Ali Raza</creator><creator>Baslaib, Fahad Omar</creator><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20130522</creationdate><title>Intracranial haemorrhage 4 days after receiving thrombolytic therapy in a young woman with myocardial infarction</title><author>Ali, Sameera Mohamed ; Rajani, Ali Raza ; Baslaib, Fahad Omar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b5116-9ed9f4796fe97da30683789bdf47d10c9d081b5d613d45f140b9d6251d4e19f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acute coronary syndromes</topic><topic>Adult</topic><topic>Cardiovascular disease</topic><topic>Chest Pain - diagnosis</topic><topic>Chest Pain - etiology</topic><topic>Coronary Occlusion - surgery</topic><topic>Coronary vessels</topic><topic>Diabetes</topic><topic>Edema</topic><topic>Emergency medical care</topic><topic>Family medical history</topic><topic>Female</topic><topic>Fibrinolytic Agents - adverse effects</topic><topic>Glucose</topic><topic>Heart attacks</topic><topic>Hemorrhage</topic><topic>Humans</topic><topic>Indian Sub-Continent</topic><topic>Intracranial Hemorrhages - chemically induced</topic><topic>Kinases</topic><topic>Middle East</topic><topic>Myocardial Infarction - diagnosis</topic><topic>Myocardial Infarction - drug therapy</topic><topic>Myocardial Infarction - surgery</topic><topic>Patients</topic><topic>Physical therapy</topic><topic>Risk factors</topic><topic>Tenecteplase</topic><topic>Thrombolytic Therapy - adverse effects</topic><topic>Tissue Plasminogen Activator - adverse effects</topic><topic>Triglycerides</topic><topic>Unexpected Outcome (Positive or Negative) Including Adverse Drug Reactions</topic><topic>Vein & artery diseases</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ali, Sameera Mohamed</creatorcontrib><creatorcontrib>Rajani, Ali Raza</creatorcontrib><creatorcontrib>Baslaib, Fahad Omar</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMJ case reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ali, Sameera Mohamed</au><au>Rajani, Ali Raza</au><au>Baslaib, Fahad Omar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intracranial haemorrhage 4 days after receiving thrombolytic therapy in a young woman with myocardial infarction</atitle><jtitle>BMJ case reports</jtitle><addtitle>BMJ Case Rep</addtitle><date>2013-05-22</date><risdate>2013</risdate><volume>2013</volume><spage>bcr2013009816</spage><pages>bcr2013009816-</pages><issn>1757-790X</issn><eissn>1757-790X</eissn><abstract>Intracranial haemorrhage is a known complication after fibrinolytic therapy and occurs usually in the first 24 h. We report a 35-year-old woman who presented with severe central chest pain and she was diagnosed as anterior ST elevation myocardial infarction. She was given fibrinolytic therapy with Tenecteplase. She responded well to the treatment with a decrease in the intensity of chest pain and resolution of the ST segment elevation. She was taken for coronary angiogram the next day, which revealed an occlusion of the left anterior descending (LAD) artery, and stenting of LAD was carried out. Four days later, she developed severe headache, confusion, slurring of speech and right haemiparesis. CT brain revealed intracerebral haemorrhage and she was referred to an neurosurgeon who advised for conservative management. Her condition gradually improved with physiotherapy and was discharged home with no marked functional impairment.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>23704457</pmid><doi>10.1136/bcr-2013-009816</doi><oa>free_for_read</oa></addata></record> |
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subjects | Acute coronary syndromes Adult Cardiovascular disease Chest Pain - diagnosis Chest Pain - etiology Coronary Occlusion - surgery Coronary vessels Diabetes Edema Emergency medical care Family medical history Female Fibrinolytic Agents - adverse effects Glucose Heart attacks Hemorrhage Humans Indian Sub-Continent Intracranial Hemorrhages - chemically induced Kinases Middle East Myocardial Infarction - diagnosis Myocardial Infarction - drug therapy Myocardial Infarction - surgery Patients Physical therapy Risk factors Tenecteplase Thrombolytic Therapy - adverse effects Tissue Plasminogen Activator - adverse effects Triglycerides Unexpected Outcome (Positive or Negative) Including Adverse Drug Reactions Vein & artery diseases Womens health |
title | Intracranial haemorrhage 4 days after receiving thrombolytic therapy in a young woman with myocardial infarction |
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