Heroin abuse accelerates biological aging: a novel insight from telomerase and brain imaging interaction
Heroin abuse and natural aging exert common influences on immunological cell functioning. This observation led to a recent and untested idea that aging may be accelerated in abusers of heroin. We examined this claim by testing whether heroin use is associated with premature aging at both cellular an...
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| Veröffentlicht in: | Translational psychiatry 2013-05, Vol.3 (5), p.e260-e260 |
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| creator | Cheng, G L F Zeng, H Leung, M-K Zhang, H-J Lau, B W M Liu, Y-P Liu, G-X Sham, P C Chan, C C H So, K-F Lee, T M C |
| description | Heroin abuse and natural aging exert common influences on immunological cell functioning. This observation led to a recent and untested idea that aging may be accelerated in abusers of heroin. We examined this claim by testing whether heroin use is associated with premature aging at both cellular and brain system levels. A group of abstinent heroin users (
n
=33) and matched healthy controls (
n
=30) were recruited and measured on various biological indicators of aging. These measures included peripheral blood telomerase activity, which reflects cellular aging, and both structural and functional measures of brain magnetic resonance imaging. We found that heroin users were characterized by significantly low telomerase activity (0.21 vs 1.78; 88% reduction;
t
(61)=6.96,
P |
| doi_str_mv | 10.1038/tp.2013.36 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3669923</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4068245851</sourcerecordid><originalsourceid>FETCH-LOGICAL-c508t-789395a84607390b069fb14f49887beb17f29f25a7a8e5b446edfb1426eb244a3</originalsourceid><addsrcrecordid>eNplkUtLAzEUhYMoKurGHyABd0prHjOZxIUg4gsEN7oOyfTONDJNapIW_PemVqViNjdwv3PugYPQMSVjSri8yPMxI5SPudhC-4zWcsSplNsb_z10lNIbKa-uJG3oLtpjXKia8XofTR8gBuexsYsE2LQtDBBNhoStC0PoXWsGbHrn-0tssA9LGLDzyfXTjLsYZjjDEGZFslL7CbbRFDc3-5IUMpdVm13wh2inM0OCo-95gF7vbl9uHkZPz_ePN9dPo7YmMo8aqbiqjawEabgilgjVWVp1lZKysWBp0zHVsdo0RkJtq0rAZAUwAZZVleEH6GrtO1_YGUxa8DmaQc9jyRQ_dDBO_914N9V9WGouhFKMF4PTb4MY3heQsn4Li-hLZk0bRbkSBSrU2ZpqY0gpQvd7gRK9KkbnuV4VU3wLfLKZ6Rf9qaEA52sglZXvIW7c_G_3CRxJmJs</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1791396233</pqid></control><display><type>article</type><title>Heroin abuse accelerates biological aging: a novel insight from telomerase and brain imaging interaction</title><source>MEDLINE</source><source>Nature Free</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Springer Nature OA Free Journals</source><creator>Cheng, G L F ; Zeng, H ; Leung, M-K ; Zhang, H-J ; Lau, B W M ; Liu, Y-P ; Liu, G-X ; Sham, P C ; Chan, C C H ; So, K-F ; Lee, T M C</creator><creatorcontrib>Cheng, G L F ; Zeng, H ; Leung, M-K ; Zhang, H-J ; Lau, B W M ; Liu, Y-P ; Liu, G-X ; Sham, P C ; Chan, C C H ; So, K-F ; Lee, T M C</creatorcontrib><description>Heroin abuse and natural aging exert common influences on immunological cell functioning. This observation led to a recent and untested idea that aging may be accelerated in abusers of heroin. We examined this claim by testing whether heroin use is associated with premature aging at both cellular and brain system levels. A group of abstinent heroin users (
n
=33) and matched healthy controls (
n
=30) were recruited and measured on various biological indicators of aging. These measures included peripheral blood telomerase activity, which reflects cellular aging, and both structural and functional measures of brain magnetic resonance imaging. We found that heroin users were characterized by significantly low telomerase activity (0.21 vs 1.78; 88% reduction;
t
(61)=6.96,
P
<0.001; 95% confidence interval=1.12–2.02), which interacted with heroin use to affect the structural integrity of gray and white matter of the prefrontal cortex (PFC; AlphaSim corrected
P
<0.05), a key brain region implicated in aging. Using the PFC location identified from the structural analyses as a ‘seed’ region, it was further revealed that telomerase activity interacted with heroin use to impact age-sensitive brain functional networks (AlphaSim corrected
P
<0.05), which correlated with behavioral performance on executive functioning, memory and attentional control (Pearson correlation, all
P
<0.05). To our knowledge, this study is the first to attempt a direct integration of peripheral molecular, brain system and behavioral measures in the context of substance abuse. The present finding that heroin abuse is associated with accelerated aging at both cellular and brain system levels is novel and forms a unique contribution to our knowledge in how the biological processes of drug abusers may be disrupted.</description><identifier>ISSN: 2158-3188</identifier><identifier>EISSN: 2158-3188</identifier><identifier>DOI: 10.1038/tp.2013.36</identifier><identifier>PMID: 23695235</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/136/7 ; 692/699/476/5 ; Adult ; Aging - drug effects ; Behavioral Sciences ; Biological Psychology ; Brain - drug effects ; Brain - pathology ; Brain - physiopathology ; Case-Control Studies ; Functional Neuroimaging ; Heroin Dependence - complications ; Heroin Dependence - pathology ; Heroin Dependence - physiopathology ; Humans ; Magnetic Resonance Imaging ; Male ; Medicine ; Medicine & Public Health ; Neuroimaging ; Neurosciences ; Original ; original-article ; Pharmacotherapy ; Psychiatry ; Telomerase - blood ; Telomerase - drug effects</subject><ispartof>Translational psychiatry, 2013-05, Vol.3 (5), p.e260-e260</ispartof><rights>The Author(s) 2013</rights><rights>Copyright Nature Publishing Group May 2013</rights><rights>Copyright © 2013 Macmillan Publishers Limited 2013 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-789395a84607390b069fb14f49887beb17f29f25a7a8e5b446edfb1426eb244a3</citedby><cites>FETCH-LOGICAL-c508t-789395a84607390b069fb14f49887beb17f29f25a7a8e5b446edfb1426eb244a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669923/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669923/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,41099,42168,51554,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23695235$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheng, G L F</creatorcontrib><creatorcontrib>Zeng, H</creatorcontrib><creatorcontrib>Leung, M-K</creatorcontrib><creatorcontrib>Zhang, H-J</creatorcontrib><creatorcontrib>Lau, B W M</creatorcontrib><creatorcontrib>Liu, Y-P</creatorcontrib><creatorcontrib>Liu, G-X</creatorcontrib><creatorcontrib>Sham, P C</creatorcontrib><creatorcontrib>Chan, C C H</creatorcontrib><creatorcontrib>So, K-F</creatorcontrib><creatorcontrib>Lee, T M C</creatorcontrib><title>Heroin abuse accelerates biological aging: a novel insight from telomerase and brain imaging interaction</title><title>Translational psychiatry</title><addtitle>Transl Psychiatry</addtitle><addtitle>Transl Psychiatry</addtitle><description>Heroin abuse and natural aging exert common influences on immunological cell functioning. This observation led to a recent and untested idea that aging may be accelerated in abusers of heroin. We examined this claim by testing whether heroin use is associated with premature aging at both cellular and brain system levels. A group of abstinent heroin users (
n
=33) and matched healthy controls (
n
=30) were recruited and measured on various biological indicators of aging. These measures included peripheral blood telomerase activity, which reflects cellular aging, and both structural and functional measures of brain magnetic resonance imaging. We found that heroin users were characterized by significantly low telomerase activity (0.21 vs 1.78; 88% reduction;
t
(61)=6.96,
P
<0.001; 95% confidence interval=1.12–2.02), which interacted with heroin use to affect the structural integrity of gray and white matter of the prefrontal cortex (PFC; AlphaSim corrected
P
<0.05), a key brain region implicated in aging. Using the PFC location identified from the structural analyses as a ‘seed’ region, it was further revealed that telomerase activity interacted with heroin use to impact age-sensitive brain functional networks (AlphaSim corrected
P
<0.05), which correlated with behavioral performance on executive functioning, memory and attentional control (Pearson correlation, all
P
<0.05). To our knowledge, this study is the first to attempt a direct integration of peripheral molecular, brain system and behavioral measures in the context of substance abuse. The present finding that heroin abuse is associated with accelerated aging at both cellular and brain system levels is novel and forms a unique contribution to our knowledge in how the biological processes of drug abusers may be disrupted.</description><subject>631/136/7</subject><subject>692/699/476/5</subject><subject>Adult</subject><subject>Aging - drug effects</subject><subject>Behavioral Sciences</subject><subject>Biological Psychology</subject><subject>Brain - drug effects</subject><subject>Brain - pathology</subject><subject>Brain - physiopathology</subject><subject>Case-Control Studies</subject><subject>Functional Neuroimaging</subject><subject>Heroin Dependence - complications</subject><subject>Heroin Dependence - pathology</subject><subject>Heroin Dependence - physiopathology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neuroimaging</subject><subject>Neurosciences</subject><subject>Original</subject><subject>original-article</subject><subject>Pharmacotherapy</subject><subject>Psychiatry</subject><subject>Telomerase - blood</subject><subject>Telomerase - drug effects</subject><issn>2158-3188</issn><issn>2158-3188</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNplkUtLAzEUhYMoKurGHyABd0prHjOZxIUg4gsEN7oOyfTONDJNapIW_PemVqViNjdwv3PugYPQMSVjSri8yPMxI5SPudhC-4zWcsSplNsb_z10lNIbKa-uJG3oLtpjXKia8XofTR8gBuexsYsE2LQtDBBNhoStC0PoXWsGbHrn-0tssA9LGLDzyfXTjLsYZjjDEGZFslL7CbbRFDc3-5IUMpdVm13wh2inM0OCo-95gF7vbl9uHkZPz_ePN9dPo7YmMo8aqbiqjawEabgilgjVWVp1lZKysWBp0zHVsdo0RkJtq0rAZAUwAZZVleEH6GrtO1_YGUxa8DmaQc9jyRQ_dDBO_914N9V9WGouhFKMF4PTb4MY3heQsn4Li-hLZk0bRbkSBSrU2ZpqY0gpQvd7gRK9KkbnuV4VU3wLfLKZ6Rf9qaEA52sglZXvIW7c_G_3CRxJmJs</recordid><startdate>20130521</startdate><enddate>20130521</enddate><creator>Cheng, G L F</creator><creator>Zeng, H</creator><creator>Leung, M-K</creator><creator>Zhang, H-J</creator><creator>Lau, B W M</creator><creator>Liu, Y-P</creator><creator>Liu, G-X</creator><creator>Sham, P C</creator><creator>Chan, C C H</creator><creator>So, K-F</creator><creator>Lee, T M C</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20130521</creationdate><title>Heroin abuse accelerates biological aging: a novel insight from telomerase and brain imaging interaction</title><author>Cheng, G L F ; Zeng, H ; Leung, M-K ; Zhang, H-J ; Lau, B W M ; Liu, Y-P ; Liu, G-X ; Sham, P C ; Chan, C C H ; So, K-F ; Lee, T M C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-789395a84607390b069fb14f49887beb17f29f25a7a8e5b446edfb1426eb244a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>631/136/7</topic><topic>692/699/476/5</topic><topic>Adult</topic><topic>Aging - drug effects</topic><topic>Behavioral Sciences</topic><topic>Biological Psychology</topic><topic>Brain - drug effects</topic><topic>Brain - pathology</topic><topic>Brain - physiopathology</topic><topic>Case-Control Studies</topic><topic>Functional Neuroimaging</topic><topic>Heroin Dependence - complications</topic><topic>Heroin Dependence - pathology</topic><topic>Heroin Dependence - physiopathology</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neuroimaging</topic><topic>Neurosciences</topic><topic>Original</topic><topic>original-article</topic><topic>Pharmacotherapy</topic><topic>Psychiatry</topic><topic>Telomerase - blood</topic><topic>Telomerase - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheng, G L F</creatorcontrib><creatorcontrib>Zeng, H</creatorcontrib><creatorcontrib>Leung, M-K</creatorcontrib><creatorcontrib>Zhang, H-J</creatorcontrib><creatorcontrib>Lau, B W M</creatorcontrib><creatorcontrib>Liu, Y-P</creatorcontrib><creatorcontrib>Liu, G-X</creatorcontrib><creatorcontrib>Sham, P C</creatorcontrib><creatorcontrib>Chan, C C H</creatorcontrib><creatorcontrib>So, K-F</creatorcontrib><creatorcontrib>Lee, T M C</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Translational psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, G L F</au><au>Zeng, H</au><au>Leung, M-K</au><au>Zhang, H-J</au><au>Lau, B W M</au><au>Liu, Y-P</au><au>Liu, G-X</au><au>Sham, P C</au><au>Chan, C C H</au><au>So, K-F</au><au>Lee, T M C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heroin abuse accelerates biological aging: a novel insight from telomerase and brain imaging interaction</atitle><jtitle>Translational psychiatry</jtitle><stitle>Transl Psychiatry</stitle><addtitle>Transl Psychiatry</addtitle><date>2013-05-21</date><risdate>2013</risdate><volume>3</volume><issue>5</issue><spage>e260</spage><epage>e260</epage><pages>e260-e260</pages><issn>2158-3188</issn><eissn>2158-3188</eissn><abstract>Heroin abuse and natural aging exert common influences on immunological cell functioning. This observation led to a recent and untested idea that aging may be accelerated in abusers of heroin. We examined this claim by testing whether heroin use is associated with premature aging at both cellular and brain system levels. A group of abstinent heroin users (
n
=33) and matched healthy controls (
n
=30) were recruited and measured on various biological indicators of aging. These measures included peripheral blood telomerase activity, which reflects cellular aging, and both structural and functional measures of brain magnetic resonance imaging. We found that heroin users were characterized by significantly low telomerase activity (0.21 vs 1.78; 88% reduction;
t
(61)=6.96,
P
<0.001; 95% confidence interval=1.12–2.02), which interacted with heroin use to affect the structural integrity of gray and white matter of the prefrontal cortex (PFC; AlphaSim corrected
P
<0.05), a key brain region implicated in aging. Using the PFC location identified from the structural analyses as a ‘seed’ region, it was further revealed that telomerase activity interacted with heroin use to impact age-sensitive brain functional networks (AlphaSim corrected
P
<0.05), which correlated with behavioral performance on executive functioning, memory and attentional control (Pearson correlation, all
P
<0.05). To our knowledge, this study is the first to attempt a direct integration of peripheral molecular, brain system and behavioral measures in the context of substance abuse. The present finding that heroin abuse is associated with accelerated aging at both cellular and brain system levels is novel and forms a unique contribution to our knowledge in how the biological processes of drug abusers may be disrupted.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>23695235</pmid><doi>10.1038/tp.2013.36</doi><oa>free_for_read</oa></addata></record> |
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| subjects | 631/136/7 692/699/476/5 Adult Aging - drug effects Behavioral Sciences Biological Psychology Brain - drug effects Brain - pathology Brain - physiopathology Case-Control Studies Functional Neuroimaging Heroin Dependence - complications Heroin Dependence - pathology Heroin Dependence - physiopathology Humans Magnetic Resonance Imaging Male Medicine Medicine & Public Health Neuroimaging Neurosciences Original original-article Pharmacotherapy Psychiatry Telomerase - blood Telomerase - drug effects |
| title | Heroin abuse accelerates biological aging: a novel insight from telomerase and brain imaging interaction |
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