Altered microRNA expression profile in Amyotrophic Lateral Sclerosis: a role in the regulation of NFL mRNA levels

Amyotrophic Lateral Sclerosis (ALS) is a progressive, adult onset, fatal neurodegenerative disease of motor neurons. There is emerging evidence that alterations in RNA metabolism may be critical in the pathogenesis of ALS. MicroRNAs (miRNAs) are small non-coding RNAs that are key determinants of mRN...

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Veröffentlicht in:	Molecular brain 2013-05, Vol.6 (1), p.26-26, Article 26
Hauptverfasser:	Campos-Melo, Danae, Droppelmann, Cristian A, He, Zhongping, Volkening, Kathryn, Strong, Michael J
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Adult Aged Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - genetics Analysis Base Sequence Biological products industry Case-Control Studies Cell death Cell Death - genetics Demography Enzymes Female Gene Expression Profiling Gene Regulatory Networks - genetics Genes Genes, Reporter - genetics HEK293 Cells Humans Luciferases - metabolism Male Medical research Messenger RNA MicroRNA MicroRNAs - genetics MicroRNAs - metabolism Middle Aged Molecular Sequence Data Mutation Mutation - genetics Nervous System - pathology Nervous System - physiopathology Nervous system diseases Neurofilament Proteins - genetics Neurofilament Proteins - metabolism Physiological aspects Proteins RNA, Messenger - genetics RNA, Messenger - metabolism Sequence Alignment Spinal Cord - metabolism Spinal Cord - pathology Up-Regulation - genetics
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