Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-mediated Calcium Signaling and Arrhythmias in the Heart Evoked by β-Adrenergic Stimulation

Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most potent Ca2+-releasing second messenger known to date. Here, we report a new role for NAADP in arrhythmogenic Ca2+ release in cardiac myocytes evoked by β-adrenergic stimulation. Infusion of NAADP into intact cardiac myocytes induced g...

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Veröffentlicht in:	The Journal of biological chemistry 2013-05, Vol.288 (22), p.16017-16030
Hauptverfasser:	Nebel, Merle, Schwoerer, Alexander P., Warszta, Dominik, Siebrands, Cornelia C., Limbrock, Ann-Christin, Swarbrick, Joanna M., Fliegert, Ralf, Weber, Karin, Bruhn, Sören, Hohenegger, Martin, Geisler, Anne, Herich, Lena, Schlegel, Susan, Carrier, Lucie, Eschenhagen, Thomas, Potter, Barry V.L., Ehmke, Heimo, Guse, Andreas H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Agonists - pharmacology Animals Arrhythmias, Cardiac - drug therapy Arrhythmias, Cardiac - metabolism Arrhythmias, Cardiac - pathology Calcium Calcium Intracellular Release Calcium Signaling - drug effects Cells, Cultured Isoproterenol - pharmacology Mice Myocardium - metabolism Myocardium - pathology Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology NAADP NADP - analogs & derivatives NADP - antagonists & inhibitors NADP - metabolism Nicotinic Acids - pharmacology Ryanodine Receptor Ryanodine Receptor Calcium Release Channel - immunology Sarcoplasmic Reticulum - metabolism Sarcoplasmic Reticulum - pathology Signal Transduction
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