Search for adenosine A2A spare receptors on peripheral human lymphocytes

Some ligand–receptor couples involve spare receptors, which are apparent when a maximal response is achieved with only a small fraction of the receptor population occupied. This situation favours cross-reactions with low-affinity ligands, which may be detrimental for cell signaling. In the case of t...

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Veröffentlicht in:	FEBS open bio 2013-01, Vol.3 (1), p.1-5
Hauptverfasser:	Jacquin, Laurent, Franceschi, Frédéric, By, Youlet, Durand-Gorde, Josée-Martine, Condo, Jocelyne, Deharo, Jean-Claude, Michelet, Pierre, Fenouillet, Emmanuel, Guieu, Régis, Ruf, Jean
Format:	Artikel
Sprache:	eng
Schlagworte:	adenosine Adenosine A2A receptor Agonist cyclic AMP dissociation humans immunosuppression ligands Lymphocyte lymphocytes mAb median effective concentration patients purinergic receptors Spare receptor
Online-Zugang:	Volltext
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