A short-term colorectal cancer sphere culture as a relevant tool for human cancer biology investigation

Background: Ex vivo colospheres have been previously characterised as a colorectal cancer (CRC) well-rounded multicellular model, exclusively formed by carcinoma cells, and derived from fresh CRC tissue after mechanical dissociation. The ability to form colospheres was correlated with tumour aggress...

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Veröffentlicht in:	British journal of cancer 2013-04, Vol.108 (8), p.1720-1731
Hauptverfasser:	Weiswald, L-B, Richon, S, Massonnet, G, Guinebretière, J-M, Vacher, S, Laurendeau, I, Cottu, P, Marangoni, E, Nemati, F, Validire, P, Bellet, D, Bièche, I, Dangles-Marie, V
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/70 692/308 692/699/67/1504/1885 Animals Biological and medical sciences Biomedical and Life Sciences Biomedicine Camptothecin - analogs & derivatives Camptothecin - pharmacology Cancer Research Cancer therapies Cell Line, Tumor Cell Movement - physiology Cell Survival - physiology Colorectal cancer Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Drug Resistance Drug Screening Assays, Antitumor Epidemiology Female Fluorouracil - pharmacology Gastroenterology. Liver. Pancreas. Abdomen Gene expression Humans Medical sciences Metastasis Mice Mice, Nude Mice, SCID Microscopy, Confocal Molecular Diagnostics Molecular Medicine Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasm Transplantation Oncology Random Allocation Real-Time Polymerase Chain Reaction Spheroids, Cellular - pathology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Transplantation, Heterologous Tumors Xenograft Model Antitumor Assays
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