Itch and analgesia resulting from intrathecal application of morphine: contrasting effects on different populations of trigeminothalamic tract neurons
Intrathecal application of morphine is among the most powerful methods used to treat severe chronic pain. However, this approach commonly produces itch sufficiently severe that patients are forced to choose between relief of pain or itch. The neuronal populations responsible for processing and trans...
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| Veröffentlicht in: | The Journal of neuroscience 2013-04, Vol.33 (14), p.6093-6101 |
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| creator | Moser, Hannah R Giesler, Jr, Glenn J |
| description | Intrathecal application of morphine is among the most powerful methods used to treat severe chronic pain. However, this approach commonly produces itch sufficiently severe that patients are forced to choose between relief of pain or itch. The neuronal populations responsible for processing and transmitting information underlying itch caused by intrathecal application of morphine have not been identified and characterized. We describe two populations of antidromically identified trigeminothalamic tract (VTT) neurons in anesthetized rats that are differentially affected by morphine and explain several aspects of opioid-induced itch and analgesia. We found that intrathecal application of morphine increased ongoing activity of itch-responsive VTT neurons. In addition, intrathecal application of morphine increased responses to pruritogens injected into the skin and greatly heightened responses to innocuous mechanical stimuli. In contrast, the ongoing activity and responses to noxious pinches in nociceptive VTT neurons were frequently inhibited by the same dose of morphine. These results reveal that i.t. application of morphine affects specific subpopulations of VTT neurons in ways that may produce itch, hyperknesis, alloknesis, and analgesia. |
| doi_str_mv | 10.1523/JNEUROSCI.0216-13.2013 |
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However, this approach commonly produces itch sufficiently severe that patients are forced to choose between relief of pain or itch. The neuronal populations responsible for processing and transmitting information underlying itch caused by intrathecal application of morphine have not been identified and characterized. We describe two populations of antidromically identified trigeminothalamic tract (VTT) neurons in anesthetized rats that are differentially affected by morphine and explain several aspects of opioid-induced itch and analgesia. We found that intrathecal application of morphine increased ongoing activity of itch-responsive VTT neurons. In addition, intrathecal application of morphine increased responses to pruritogens injected into the skin and greatly heightened responses to innocuous mechanical stimuli. In contrast, the ongoing activity and responses to noxious pinches in nociceptive VTT neurons were frequently inhibited by the same dose of morphine. These results reveal that i.t. application of morphine affects specific subpopulations of VTT neurons in ways that may produce itch, hyperknesis, alloknesis, and analgesia.</description><identifier>ISSN: 0270-6474</identifier><identifier>ISSN: 1529-2401</identifier><identifier>EISSN: 1529-2401</identifier><identifier>DOI: 10.1523/JNEUROSCI.0216-13.2013</identifier><identifier>PMID: 23554490</identifier><language>eng</language><publisher>United States: Society for Neuroscience</publisher><subject>Action Potentials - drug effects ; Analgesics, Opioid - administration & dosage ; Analgesics, Opioid - adverse effects ; Animals ; Antirheumatic Agents - pharmacology ; Chloroquine - pharmacology ; Electric Stimulation ; Histamine - pharmacology ; Injections, Spinal - methods ; Male ; Morphine - administration & dosage ; Morphine - adverse effects ; Neural Pathways - drug effects ; Pain - drug therapy ; Peptide Fragments - pharmacology ; Pruritus - chemically induced ; Rats ; Rats, Sprague-Dawley ; Reaction Time - drug effects ; Serotonin - pharmacology ; Stimulation, Chemical ; Thalamus - cytology ; Thalamus - injuries ; Trigeminal Nuclei - cytology ; Trigeminal Nuclei - injuries</subject><ispartof>The Journal of neuroscience, 2013-04, Vol.33 (14), p.6093-6101</ispartof><rights>Copyright © 2013 the authors 0270-6474/13/336093-09$15.00/0 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-d268547595377f219bfbe6cb66a7e11b719c1700f160d0e8fab97c9c2bf7e9223</citedby><cites>FETCH-LOGICAL-c447t-d268547595377f219bfbe6cb66a7e11b719c1700f160d0e8fab97c9c2bf7e9223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668454/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668454/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23554490$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moser, Hannah R</creatorcontrib><creatorcontrib>Giesler, Jr, Glenn J</creatorcontrib><title>Itch and analgesia resulting from intrathecal application of morphine: contrasting effects on different populations of trigeminothalamic tract neurons</title><title>The Journal of neuroscience</title><addtitle>J Neurosci</addtitle><description>Intrathecal application of morphine is among the most powerful methods used to treat severe chronic pain. However, this approach commonly produces itch sufficiently severe that patients are forced to choose between relief of pain or itch. The neuronal populations responsible for processing and transmitting information underlying itch caused by intrathecal application of morphine have not been identified and characterized. We describe two populations of antidromically identified trigeminothalamic tract (VTT) neurons in anesthetized rats that are differentially affected by morphine and explain several aspects of opioid-induced itch and analgesia. We found that intrathecal application of morphine increased ongoing activity of itch-responsive VTT neurons. In addition, intrathecal application of morphine increased responses to pruritogens injected into the skin and greatly heightened responses to innocuous mechanical stimuli. In contrast, the ongoing activity and responses to noxious pinches in nociceptive VTT neurons were frequently inhibited by the same dose of morphine. These results reveal that i.t. application of morphine affects specific subpopulations of VTT neurons in ways that may produce itch, hyperknesis, alloknesis, and analgesia.</description><subject>Action Potentials - drug effects</subject><subject>Analgesics, Opioid - administration & dosage</subject><subject>Analgesics, Opioid - adverse effects</subject><subject>Animals</subject><subject>Antirheumatic Agents - pharmacology</subject><subject>Chloroquine - pharmacology</subject><subject>Electric Stimulation</subject><subject>Histamine - pharmacology</subject><subject>Injections, Spinal - methods</subject><subject>Male</subject><subject>Morphine - administration & dosage</subject><subject>Morphine - adverse effects</subject><subject>Neural Pathways - drug effects</subject><subject>Pain - drug therapy</subject><subject>Peptide Fragments - pharmacology</subject><subject>Pruritus - chemically induced</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reaction Time - drug effects</subject><subject>Serotonin - pharmacology</subject><subject>Stimulation, Chemical</subject><subject>Thalamus - cytology</subject><subject>Thalamus - injuries</subject><subject>Trigeminal Nuclei - cytology</subject><subject>Trigeminal Nuclei - injuries</subject><issn>0270-6474</issn><issn>1529-2401</issn><issn>1529-2401</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkd9qFDEUhwdR7Fp9hZJLb2bN_2y8EGSpdaVYUHsdMplkJ5KZjElG8EV83mbauuiVFyEh5_sO5_BrmgsEt4hh8ubT58vbLzdf94ctxIi3iGwxRORJs6lV2WIK0dNmA7GALaeCnjUvcv4OIRQQiefNGSaMUSrhpvl9KGYAeurr0eFos9cg2byE4qcjcCmOwE8l6TJYowPQ8xy80cXHCUQHxpjmwU_2LTBxpfK9ZZ2zpmRQmd7Xd7JTAXOcl3Av5tUsyR_t6KdYBh306E390aaAyS6pIi-bZ06HbF893ufN7YfLb_uP7fXN1WH__ro1lIrS9pjvGBVMMiKEw0h2rrPcdJxrYRHqBJIGCQgd4rCHdud0J4WRBndOWIkxOW_ePfSdl260vbHrFkHNyY86_VJRe_VvZfKDOsafinC-o4zWBq8fG6T4Y7G5qNFnY0PQk41LVogxxDGEnP0fJZiSHZVUVpQ_oCbFnJN1p4kQVGv-6pS_WvOvrlrzr-LF3_uctD-BkzvAE7Ir</recordid><startdate>20130403</startdate><enddate>20130403</enddate><creator>Moser, Hannah R</creator><creator>Giesler, Jr, Glenn J</creator><general>Society for Neuroscience</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20130403</creationdate><title>Itch and analgesia resulting from intrathecal application of morphine: contrasting effects on different populations of trigeminothalamic tract neurons</title><author>Moser, Hannah R ; Giesler, Jr, Glenn J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-d268547595377f219bfbe6cb66a7e11b719c1700f160d0e8fab97c9c2bf7e9223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Action Potentials - drug effects</topic><topic>Analgesics, Opioid - administration & dosage</topic><topic>Analgesics, Opioid - adverse effects</topic><topic>Animals</topic><topic>Antirheumatic Agents - pharmacology</topic><topic>Chloroquine - pharmacology</topic><topic>Electric Stimulation</topic><topic>Histamine - pharmacology</topic><topic>Injections, Spinal - methods</topic><topic>Male</topic><topic>Morphine - administration & dosage</topic><topic>Morphine - adverse effects</topic><topic>Neural Pathways - drug effects</topic><topic>Pain - drug therapy</topic><topic>Peptide Fragments - pharmacology</topic><topic>Pruritus - chemically induced</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reaction Time - drug effects</topic><topic>Serotonin - pharmacology</topic><topic>Stimulation, Chemical</topic><topic>Thalamus - cytology</topic><topic>Thalamus - injuries</topic><topic>Trigeminal Nuclei - cytology</topic><topic>Trigeminal Nuclei - injuries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moser, Hannah R</creatorcontrib><creatorcontrib>Giesler, Jr, Glenn J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moser, Hannah R</au><au>Giesler, Jr, Glenn J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Itch and analgesia resulting from intrathecal application of morphine: contrasting effects on different populations of trigeminothalamic tract neurons</atitle><jtitle>The Journal of neuroscience</jtitle><addtitle>J Neurosci</addtitle><date>2013-04-03</date><risdate>2013</risdate><volume>33</volume><issue>14</issue><spage>6093</spage><epage>6101</epage><pages>6093-6101</pages><issn>0270-6474</issn><issn>1529-2401</issn><eissn>1529-2401</eissn><abstract>Intrathecal application of morphine is among the most powerful methods used to treat severe chronic pain. However, this approach commonly produces itch sufficiently severe that patients are forced to choose between relief of pain or itch. The neuronal populations responsible for processing and transmitting information underlying itch caused by intrathecal application of morphine have not been identified and characterized. We describe two populations of antidromically identified trigeminothalamic tract (VTT) neurons in anesthetized rats that are differentially affected by morphine and explain several aspects of opioid-induced itch and analgesia. We found that intrathecal application of morphine increased ongoing activity of itch-responsive VTT neurons. In addition, intrathecal application of morphine increased responses to pruritogens injected into the skin and greatly heightened responses to innocuous mechanical stimuli. In contrast, the ongoing activity and responses to noxious pinches in nociceptive VTT neurons were frequently inhibited by the same dose of morphine. These results reveal that i.t. application of morphine affects specific subpopulations of VTT neurons in ways that may produce itch, hyperknesis, alloknesis, and analgesia.</abstract><cop>United States</cop><pub>Society for Neuroscience</pub><pmid>23554490</pmid><doi>10.1523/JNEUROSCI.0216-13.2013</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Action Potentials - drug effects Analgesics, Opioid - administration & dosage Analgesics, Opioid - adverse effects Animals Antirheumatic Agents - pharmacology Chloroquine - pharmacology Electric Stimulation Histamine - pharmacology Injections, Spinal - methods Male Morphine - administration & dosage Morphine - adverse effects Neural Pathways - drug effects Pain - drug therapy Peptide Fragments - pharmacology Pruritus - chemically induced Rats Rats, Sprague-Dawley Reaction Time - drug effects Serotonin - pharmacology Stimulation, Chemical Thalamus - cytology Thalamus - injuries Trigeminal Nuclei - cytology Trigeminal Nuclei - injuries |
| title | Itch and analgesia resulting from intrathecal application of morphine: contrasting effects on different populations of trigeminothalamic tract neurons |
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