Proton channel HVCN1 is required for effector functions of mouse eosinophils

Proton currents are required for optimal respiratory burst in phagocytes. Recently, HVCN1 was identified as the molecule required for the voltage-gated proton channel activity associated with the respiratory burst in neutrophils. Although there are similarities between eosinophils and neutrophils re...

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Veröffentlicht in:	BMC immunology 2013-05, Vol.14 (1), p.24-24, Article 24
Hauptverfasser:	Zhu, Xiang, Mose, Eucabeth, Zimmermann, Nives
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidification Acids Acids - metabolism Allergies Animals Apoptosis B cells Bone marrow Calcium - metabolism Cell death Cell Death - drug effects Cell Movement - drug effects Cells Cytosol - drug effects Cytosol - metabolism Enzymes Eosinophils - cytology Eosinophils - drug effects Eosinophils - metabolism Experiments Gene expression Gene Expression Regulation - drug effects Hospitals Ion Channel Gating - drug effects Ion Channels - deficiency Ion Channels - genetics Ion Channels - metabolism Lung - drug effects Lung - metabolism Membrane Potentials - drug effects Mice Mice, Inbred C57BL Migration Oxidases Oxygen Physiological aspects Proteins Protons Reactive Oxygen Species - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Studies Tetradecanoylphorbol Acetate - pharmacology
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