$Analysis of the potential effect of ponatinib on the QTc interval in patients with refractory hematological malignancies$

Analysis of the potential effect of ponatinib on the QTc interval in patients with refractory hematological malignancies

Purpose Cardiac dysfunction, particularly QT interval prolongation, has been observed with tyrosine kinase inhibitors approved to treat chronic myeloid leukemia. This study examines the effects of ponatinib on cardiac repolarization in patients with refractory hematological malignancies enrolled in...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2013-06, Vol.71 (6), p.1599-1607
Hauptverfasser:	Sonnichsen, Daryl, Dorer, David J., Cortes, Jorge, Talpaz, Moshe, Deininger, Michael W., Shah, Neil P., Kantarjian, Hagop M., Bixby, Dale, Mauro, Michael J., Flinn, Ian W., Litwin, Jeffrey, Turner, Christopher D., Haluska, Frank G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antineoplastic agents Biological and medical sciences Cancer Research Chromosome aberrations Dose-Response Relationship, Drug Electrocardiography Female Heart - drug effects Hematologic and hematopoietic diseases Hematologic Neoplasms - drug therapy Humans Imidazoles - administration & dosage Imidazoles - adverse effects Imidazoles - blood Imidazoles - therapeutic use Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Long QT Syndrome - chemically induced Male Medical genetics Medical sciences Medicine Medicine & Public Health Middle Aged Models, Biological Oncology Original Original Article Pharmacology. Drug treatments Pharmacology/Toxicology Protein Kinase Inhibitors - administration & dosage Protein Kinase Inhibitors - adverse effects Protein Kinase Inhibitors - blood Protein Kinase Inhibitors - therapeutic use Pyridazines - administration & dosage Pyridazines - adverse effects Pyridazines - blood Pyridazines - therapeutic use
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