Cinnamic acid induces apoptotic cell death and cytoskeleton disruption in human melanoma cells

Anticancer activities of cinnamic acid derivatives include induction of apoptosis by irreversible DNA damage leading to cell death. The present work aimed to compare the cytotoxic and genotoxic potential of cinnamic acid in human melanoma cell line (HT-144) and human melanocyte cell line derived fro...

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Veröffentlicht in:	Journal of experimental & clinical cancer research 2013-05, Vol.32 (1), p.31-31, Article 31
Hauptverfasser:	Niero, Evandro Luís de Oliveira, Machado-Santelli, Gláucia Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects Berries Cancer Care and treatment Caspase 9 - metabolism Cell Cycle - drug effects Cell death Cell Line, Tumor Cell lines Cell Nucleus - drug effects Cell Survival - drug effects Chromosome Aberrations - drug effects Cinnamates - pharmacology Cinnamates - toxicity Cytoskeleton Cytoskeleton - metabolism DNA synthesis Enzymes Food science Gene expression Humans Melanoma Melanoma - metabolism Microtubules - metabolism Phosphorylation - drug effects Physiological aspects Studies Tubulin - metabolism Tumor Suppressor Protein p53 - metabolism
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