Post-exposure vaccination with MP-12 lacking NSs protects mice against lethal Rift Valley fever virus challenge

•A model of RVFV infection in C57BL/6 mice was used for post-exposure vaccination studies.•Early post-exposure vaccination with NSs deletion viruses improves survival outcome.•Reduced viral loads and disease severity are associated with post-exposure vaccination efficacy. Rift Valley fever virus (RV...

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Veröffentlicht in:	Antiviral research 2013-05, Vol.98 (2), p.135-143
Hauptverfasser:	Gowen, Brian B., Bailey, Kevin W., Scharton, Dionna, Vest, Zachery, Westover, Jonna B., Skirpstunas, Ramona, Ikegami, Tetsuro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Female Humans Medical sciences Mice Mice, Inbred C57BL Pharmacology. Drug treatments Phlebovirus Post-Exposure Prophylaxis Post-exposure vaccination Rift Valley Fever - immunology Rift Valley Fever - prevention & control Rift Valley Fever - virology Rift Valley fever virus Rift Valley fever virus - genetics Rift Valley fever virus - immunology Rift Valley fever virus - physiology Treatment Vaccination Vaccines, Attenuated - administration & dosage Vaccines, Attenuated - genetics Vaccines, Attenuated - immunology Viral hemorrhagic fever Viral Nonstructural Proteins - genetics Viral Vaccines - administration & dosage Viral Vaccines - genetics Viral Vaccines - immunology Virus Replication
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